Lubeluzole and conditioned learning after cerebral ischemia

Rashmi N. Mueller, Donald J. Deyo, David R. Brantley, John F. Disterhoft, Mark H. Zornow

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Lubeluzole [S-4-(2-benzothiazolylmethylamino)-α -((3,4-difluorophenoxy)methyl)-1-piperidineethanol] reduces the severity of cerebral injury in animal models of brain ischemia. Its beneficial effects may include decreased concentration of extracellular glutamate, blockade of sodium and calcium channels, and attenuation of nitric oxide-mediated neuronal death. Previous studies have shown that global cerebral ischemia in rabbits impaired the subsequent acquisition of a trace-conditioned eyeblink reflex. Here, we examined the effect of preischemic treatment with lubeluzole on the acquisition of a trace-conditioned eyeblink response after 6.5 min of global cerebral ischemia. Three groups of rabbits underwent cerebral ischemia: one group underwent ischemia alone (I) and two groups underwent ischemia and also received lubeluzole (L1, 1.25 mg/kg, and L2, 2.5 mg/kg). All animals were subsequently trained using classical trace conditioning. Each training session consisted of the presentation of the conditioned stimulus (an 85-dB, 6-kHz auditory tone lasting for 100 ms) followed by a trace interval (a period of 300 ms during which no external stimulus was delivered) followed finally by the delivery of the unconditioned stimulus (a 150-ms puff of air directed at the cornea). We found that animals receiving preischemic administration of 1.25 mg/kg of lubeluzole demonstrated a significantly improved acquisition of the trace-conditioned reflex as compared to animals that did not receive lubeluzole. This finding demonstrates improved long-term neurobehavioral outcome with preischemic administration of 1.25 mg/kg of lubeluzole.

    Original languageEnglish (US)
    Pages (from-to)329-334
    Number of pages6
    JournalExperimental Brain Research
    Volume152
    Issue number3
    DOIs
    StatePublished - Oct 2003

    Fingerprint

    lubeluzole
    Brain Ischemia
    Learning
    Classical Conditioning
    Ischemia
    Rabbits
    Sodium Channels
    Calcium Channels
    Cornea
    Glutamic Acid
    Nitric Oxide
    Animal Models
    Air

    Keywords

    • Conditioning
    • Eyeblink
    • Global cerebral ischemia
    • Lubeluzole
    • Neuroprotection
    • Rabbits

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Mueller, R. N., Deyo, D. J., Brantley, D. R., Disterhoft, J. F., & Zornow, M. H. (2003). Lubeluzole and conditioned learning after cerebral ischemia. Experimental Brain Research, 152(3), 329-334. https://doi.org/10.1007/s00221-003-1539-9

    Lubeluzole and conditioned learning after cerebral ischemia. / Mueller, Rashmi N.; Deyo, Donald J.; Brantley, David R.; Disterhoft, John F.; Zornow, Mark H.

    In: Experimental Brain Research, Vol. 152, No. 3, 10.2003, p. 329-334.

    Research output: Contribution to journalArticle

    Mueller, RN, Deyo, DJ, Brantley, DR, Disterhoft, JF & Zornow, MH 2003, 'Lubeluzole and conditioned learning after cerebral ischemia', Experimental Brain Research, vol. 152, no. 3, pp. 329-334. https://doi.org/10.1007/s00221-003-1539-9
    Mueller RN, Deyo DJ, Brantley DR, Disterhoft JF, Zornow MH. Lubeluzole and conditioned learning after cerebral ischemia. Experimental Brain Research. 2003 Oct;152(3):329-334. https://doi.org/10.1007/s00221-003-1539-9
    Mueller, Rashmi N. ; Deyo, Donald J. ; Brantley, David R. ; Disterhoft, John F. ; Zornow, Mark H. / Lubeluzole and conditioned learning after cerebral ischemia. In: Experimental Brain Research. 2003 ; Vol. 152, No. 3. pp. 329-334.
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