Abstract
We investigated the contribution of the bronchial blood flow to the lung lymph flow (Q̇(L)) and lung edema formation after inhalation injury in sheep (n = 18). The animals were equally divided into three groups and chronically prepared by implantation of cardiopulmonary catheters and a flow probe on the common bronchial artery. Groups 1 and 2 sheep were insufflated with 48 breaths of cotton smoke while group 3 received only room air. Just before injury, the bronchial artery of group 2 animals was occluded. The occlusion was maintained for the duration of the 24-h study period. At the end of the investigation, samples of lung were taken for determination of blood-free wet weight-to-dry weight ratio (W/D). Inhalation injury induced a sevenfold increase in Q̇(L) in group 1 (7 ± 1 to 50 ± 9 ml/h; P < 0.05) but only a threefold increase in group 2 (10 ± 2 to 28 ± 7 ml/h; P < 0.05). The mean W/D value of group 1 animals was 23% higher than that of group 2 (5.1 ± 0.4 vs. 3.9 ± 0.2; P < 0.05). Our data suggest that the bronchial circulation contributes to edema formation in the lung that is often seen after the acute lung injury with smoke inhalation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 727-734 |
| Number of pages | 8 |
| Journal | Journal of Applied Physiology |
| Volume | 71 |
| Issue number | 2 |
| State | Published - 1991 |
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Keywords
- airway blood flow
- bronchial artery occlusion
- cotton smoke
- extravascular lung water
- lung fluid flux
- microvasculature
- permeability changes
- sheep model
- ultrasonic flow probe
ASJC Scopus subject areas
- Physiology
- Endocrinology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Lung edema formation following inhalation injury : Role of the bronchial blood flow. / Abdi, S.; Herndon, David; Traber, L. D.; Ashley, K. D.; Stothert, J. C.; Maguire, J.; Butler, R.; Traber, D. L.
In: Journal of Applied Physiology, Vol. 71, No. 2, 1991, p. 727-734.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lung edema formation following inhalation injury
T2 - Role of the bronchial blood flow
AU - Abdi, S.
AU - Herndon, David
AU - Traber, L. D.
AU - Ashley, K. D.
AU - Stothert, J. C.
AU - Maguire, J.
AU - Butler, R.
AU - Traber, D. L.
PY - 1991
Y1 - 1991
N2 - We investigated the contribution of the bronchial blood flow to the lung lymph flow (Q̇(L)) and lung edema formation after inhalation injury in sheep (n = 18). The animals were equally divided into three groups and chronically prepared by implantation of cardiopulmonary catheters and a flow probe on the common bronchial artery. Groups 1 and 2 sheep were insufflated with 48 breaths of cotton smoke while group 3 received only room air. Just before injury, the bronchial artery of group 2 animals was occluded. The occlusion was maintained for the duration of the 24-h study period. At the end of the investigation, samples of lung were taken for determination of blood-free wet weight-to-dry weight ratio (W/D). Inhalation injury induced a sevenfold increase in Q̇(L) in group 1 (7 ± 1 to 50 ± 9 ml/h; P < 0.05) but only a threefold increase in group 2 (10 ± 2 to 28 ± 7 ml/h; P < 0.05). The mean W/D value of group 1 animals was 23% higher than that of group 2 (5.1 ± 0.4 vs. 3.9 ± 0.2; P < 0.05). Our data suggest that the bronchial circulation contributes to edema formation in the lung that is often seen after the acute lung injury with smoke inhalation.
AB - We investigated the contribution of the bronchial blood flow to the lung lymph flow (Q̇(L)) and lung edema formation after inhalation injury in sheep (n = 18). The animals were equally divided into three groups and chronically prepared by implantation of cardiopulmonary catheters and a flow probe on the common bronchial artery. Groups 1 and 2 sheep were insufflated with 48 breaths of cotton smoke while group 3 received only room air. Just before injury, the bronchial artery of group 2 animals was occluded. The occlusion was maintained for the duration of the 24-h study period. At the end of the investigation, samples of lung were taken for determination of blood-free wet weight-to-dry weight ratio (W/D). Inhalation injury induced a sevenfold increase in Q̇(L) in group 1 (7 ± 1 to 50 ± 9 ml/h; P < 0.05) but only a threefold increase in group 2 (10 ± 2 to 28 ± 7 ml/h; P < 0.05). The mean W/D value of group 1 animals was 23% higher than that of group 2 (5.1 ± 0.4 vs. 3.9 ± 0.2; P < 0.05). Our data suggest that the bronchial circulation contributes to edema formation in the lung that is often seen after the acute lung injury with smoke inhalation.
KW - airway blood flow
KW - bronchial artery occlusion
KW - cotton smoke
KW - extravascular lung water
KW - lung fluid flux
KW - microvasculature
KW - permeability changes
KW - sheep model
KW - ultrasonic flow probe
UR - http://www.scopus.com/inward/record.url?scp=0026075010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026075010&partnerID=8YFLogxK
M3 - Article
C2 - 1938747
AN - SCOPUS:0026075010
VL - 71
SP - 727
EP - 734
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 2
ER -