Abstract
We investigated the contribution of the bronchial blood flow to the lung lymph flow (Q̇(L)) and lung edema formation after inhalation injury in sheep (n = 18). The animals were equally divided into three groups and chronically prepared by implantation of cardiopulmonary catheters and a flow probe on the common bronchial artery. Groups 1 and 2 sheep were insufflated with 48 breaths of cotton smoke while group 3 received only room air. Just before injury, the bronchial artery of group 2 animals was occluded. The occlusion was maintained for the duration of the 24-h study period. At the end of the investigation, samples of lung were taken for determination of blood-free wet weight-to-dry weight ratio (W/D). Inhalation injury induced a sevenfold increase in Q̇(L) in group 1 (7 ± 1 to 50 ± 9 ml/h; P < 0.05) but only a threefold increase in group 2 (10 ± 2 to 28 ± 7 ml/h; P < 0.05). The mean W/D value of group 1 animals was 23% higher than that of group 2 (5.1 ± 0.4 vs. 3.9 ± 0.2; P < 0.05). Our data suggest that the bronchial circulation contributes to edema formation in the lung that is often seen after the acute lung injury with smoke inhalation.
Original language | English (US) |
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Pages (from-to) | 727-734 |
Number of pages | 8 |
Journal | Journal of Applied Physiology |
Volume | 71 |
Issue number | 2 |
DOIs | |
State | Published - 1991 |
Keywords
- airway blood flow
- bronchial artery occlusion
- cotton smoke
- extravascular lung water
- lung fluid flux
- microvasculature
- permeability changes
- sheep model
- ultrasonic flow probe
ASJC Scopus subject areas
- Physiology
- Physiology (medical)