Lung Regeneration. The Bioengineering Approach.

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pulmonary disease is a worldwide public health problem that reduces the quality of life and increases the need for hospital admissions as well as the risk for premature death for those affected. For many patients lung transplantation is the only chance for survival. Unfortunately, there is a significant shortage of lungs for transplantation, and many patients die before receiving a transplant. Recent use of acellular (AC) natural lung scaffolds by a number of research groups to engineer lung tissue has been a major scientific contribution to the field. These studies showed that engineered lung tissues grown in vitro are capable of surviving after in vivo transplantation and are able to support limited gas exchange in animal models. This manuscript discusses recent advances in the engineering of lung tissues as well as goals yet to be met in order to produce tissues worthy of clinical application in the future.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages691-706
Number of pages16
ISBN (Print)9780123985231
DOIs
StatePublished - 2014

Fingerprint

Bioengineering
Regeneration
Tissue
Lung
Lung Transplantation
Transplantation (surgical)
Pulmonary diseases
Transplants
Premature Mortality
Public health
Tissue Engineering
Medical problems
Scaffolds
Lung Diseases
Animals
Animal Models
Public Health
Transplantation
Gases
Quality of Life

Keywords

  • Acellular lung scaffolds
  • Decellularization systems
  • Detergents for decellularization
  • Engineered lung
  • GLP related to lung
  • Lung ECM
  • Natural lung scaffold
  • Tissue engineering

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nichols, J., & Cortiella, J. (2014). Lung Regeneration. The Bioengineering Approach. In Regenerative Medicine Applications in Organ Transplantation (pp. 691-706). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398523-1.00048-3

Lung Regeneration. The Bioengineering Approach. / Nichols, Joan; Cortiella, Joaquin.

Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., 2014. p. 691-706.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nichols, J & Cortiella, J 2014, Lung Regeneration. The Bioengineering Approach. in Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., pp. 691-706. https://doi.org/10.1016/B978-0-12-398523-1.00048-3
Nichols J, Cortiella J. Lung Regeneration. The Bioengineering Approach. In Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc. 2014. p. 691-706 https://doi.org/10.1016/B978-0-12-398523-1.00048-3
Nichols, Joan ; Cortiella, Joaquin. / Lung Regeneration. The Bioengineering Approach. Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., 2014. pp. 691-706
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