Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore

J. E. Childs, G. E. Glass, G. W. Korch, Thomas Ksiazek, James LeDuc

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Four hundred eighty house mice (Mus musculus) were trapped primarily from urban sites in Baltimore, Maryland from 1984 to 1989 and tested for antibody to lymphocytic choriomeningitis virus (LCMV). The majority of mice (95%) were trapped in residences at two city locations (n = 260), or in an urban park (n = 196); five additional sites were sampled. Overall, 9.0% of the mice were LCMV antibody positive and infected animals were obtained from six of eight sites, including all three of the primary city sites, where the prevalence varied significantly (3.9-13.4%). The location with the highest prevalence was an inner city residential site where positive mice were found significantly clustered within blocks and households. In this location, LCMV antibody prevalence was also significantly correlated with estimates of mouse density within individual blocks. The focal nature of LCMV infection in house mice may result from contact or vertical transmission of virus in conjunction with the highly structured social system of mice, which promotes inbreeding and limited dispersal.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume47
Issue number1 II SUPPL.
StatePublished - 1992
Externally publishedYes

Fingerprint

Lymphocytic choriomeningitis virus
Baltimore
Virus Diseases
Antibodies
Inbreeding
Viruses

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore. / Childs, J. E.; Glass, G. E.; Korch, G. W.; Ksiazek, Thomas; LeDuc, James.

In: American Journal of Tropical Medicine and Hygiene, Vol. 47, No. 1 II SUPPL., 1992, p. 27-34.

Research output: Contribution to journalArticle

@article{43fa6e438d6143b6b78eb2d518e65d06,
title = "Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore",
abstract = "Four hundred eighty house mice (Mus musculus) were trapped primarily from urban sites in Baltimore, Maryland from 1984 to 1989 and tested for antibody to lymphocytic choriomeningitis virus (LCMV). The majority of mice (95{\%}) were trapped in residences at two city locations (n = 260), or in an urban park (n = 196); five additional sites were sampled. Overall, 9.0{\%} of the mice were LCMV antibody positive and infected animals were obtained from six of eight sites, including all three of the primary city sites, where the prevalence varied significantly (3.9-13.4{\%}). The location with the highest prevalence was an inner city residential site where positive mice were found significantly clustered within blocks and households. In this location, LCMV antibody prevalence was also significantly correlated with estimates of mouse density within individual blocks. The focal nature of LCMV infection in house mice may result from contact or vertical transmission of virus in conjunction with the highly structured social system of mice, which promotes inbreeding and limited dispersal.",
author = "Childs, {J. E.} and Glass, {G. E.} and Korch, {G. W.} and Thomas Ksiazek and James LeDuc",
year = "1992",
language = "English (US)",
volume = "47",
pages = "27--34",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "1 II SUPPL.",

}

TY - JOUR

T1 - Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore

AU - Childs, J. E.

AU - Glass, G. E.

AU - Korch, G. W.

AU - Ksiazek, Thomas

AU - LeDuc, James

PY - 1992

Y1 - 1992

N2 - Four hundred eighty house mice (Mus musculus) were trapped primarily from urban sites in Baltimore, Maryland from 1984 to 1989 and tested for antibody to lymphocytic choriomeningitis virus (LCMV). The majority of mice (95%) were trapped in residences at two city locations (n = 260), or in an urban park (n = 196); five additional sites were sampled. Overall, 9.0% of the mice were LCMV antibody positive and infected animals were obtained from six of eight sites, including all three of the primary city sites, where the prevalence varied significantly (3.9-13.4%). The location with the highest prevalence was an inner city residential site where positive mice were found significantly clustered within blocks and households. In this location, LCMV antibody prevalence was also significantly correlated with estimates of mouse density within individual blocks. The focal nature of LCMV infection in house mice may result from contact or vertical transmission of virus in conjunction with the highly structured social system of mice, which promotes inbreeding and limited dispersal.

AB - Four hundred eighty house mice (Mus musculus) were trapped primarily from urban sites in Baltimore, Maryland from 1984 to 1989 and tested for antibody to lymphocytic choriomeningitis virus (LCMV). The majority of mice (95%) were trapped in residences at two city locations (n = 260), or in an urban park (n = 196); five additional sites were sampled. Overall, 9.0% of the mice were LCMV antibody positive and infected animals were obtained from six of eight sites, including all three of the primary city sites, where the prevalence varied significantly (3.9-13.4%). The location with the highest prevalence was an inner city residential site where positive mice were found significantly clustered within blocks and households. In this location, LCMV antibody prevalence was also significantly correlated with estimates of mouse density within individual blocks. The focal nature of LCMV infection in house mice may result from contact or vertical transmission of virus in conjunction with the highly structured social system of mice, which promotes inbreeding and limited dispersal.

UR - http://www.scopus.com/inward/record.url?scp=0026752603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026752603&partnerID=8YFLogxK

M3 - Article

VL - 47

SP - 27

EP - 34

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 1 II SUPPL.

ER -