Lymphoid cell infection by measles virus in newborn hamsters. Role for monocytes in virus spread to distant sites

Robert R. McKendall, Donald R. Carrigan, Kenneth P. Johnson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Following intraperitoneal inoculation of measles (HBS) virus into newborn hamsters widespread but variable productive lymphoid tissue infection was detected by a sensitive viral isolation technique. Peritoneal wash cells and spleen were the most common sites of infection. Virus was frequently isolated from the bone marrow and was commonly found in multiple lymph nodes. Thymic infection was only rarely demonstrated. A mononuclear cell associated viremia was demonstrated by Ficoll-hypaque fractionation of peripheral blood from animals receiving both high- and low-dose virus. Infection was present in both plastic adherent and non-adherent fractions of the blood mononuclear cells. The infected cell population in the spleen had both nylon wool and plastic adherent characteristics and infection was therefore thought to be macrophage-associated. The possible relevance of such macrophage associated infection is discussed with regard to the pathogenesis of natural measles infection and the immunosuppression observed in measles-infected hosts.

Original languageEnglish (US)
Pages (from-to)261-274
Number of pages14
JournalJournal of Neuroimmunology
Volume1
Issue number3
DOIs
StatePublished - 1981

Fingerprint

Measles virus
Cricetinae
Monocytes
Lymphocytes
Viruses
Infection
Measles
Plastics
Spleen
Macrophages
Diatrizoate
Ficoll
Wool
Viremia
Nylons
Lymphoid Tissue
Immunosuppression
Blood Cells
Lymph Nodes
Bone Marrow

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Lymphoid cell infection by measles virus in newborn hamsters. Role for monocytes in virus spread to distant sites. / McKendall, Robert R.; Carrigan, Donald R.; Johnson, Kenneth P.

In: Journal of Neuroimmunology, Vol. 1, No. 3, 1981, p. 261-274.

Research output: Contribution to journalArticle

McKendall, Robert R. ; Carrigan, Donald R. ; Johnson, Kenneth P. / Lymphoid cell infection by measles virus in newborn hamsters. Role for monocytes in virus spread to distant sites. In: Journal of Neuroimmunology. 1981 ; Vol. 1, No. 3. pp. 261-274.
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