Lymphoreticular and myeloid pathogenesis of Venezuelan equine encephalitis in hamsters

David Walker, A. Harrison, K. Murphy, M. Flemister, F. A. Murphy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Ultrastructural, histopathologic, and virologic studies of adult hamsters infected with virulent Venezuelan equine encephalomyelitis (VEE) virus (Subtype I B) demonstrated precise chronologic and topographic progression of lesions and viral replication in extraneural sites. Thymus contained the earliest lesions and the highest initial and subsequent viral titers. No particular cytotropism was observed as highly efficient viral replication and severe cytonecrosis proceeded. Early cortical necrosis of splenic periarteriolar lymphocytic sheath was followed by lymphoblastoid repopulation of the peripheral zone. Massive bone marrow necrosis was accompanied by ultrastructural evidence of VEE viral particle production in reticulum cells, rubricytes, myeloid cells, lymphoblastoid cells, and megakaryocytes. Speed, efficiency, destructiveness, and relative sensitivity of virtually all lymphoreticular and hematopoietic cells were hallmarks of virulent VEE infection in the hamster.

Original languageEnglish (US)
Pages (from-to)351-370
Number of pages20
JournalAmerican Journal of Pathology
Volume84
Issue number2
StatePublished - 1976
Externally publishedYes

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Venezuelan Equine Encephalomyelitides
Cricetinae
Venezuelan Equine Encephalitis Viruses
Reticulum
Megakaryocytes
Osteonecrosis
Myeloid Cells
Virion
Thymus Gland
Necrosis
Bone Marrow
Infection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Walker, D., Harrison, A., Murphy, K., Flemister, M., & Murphy, F. A. (1976). Lymphoreticular and myeloid pathogenesis of Venezuelan equine encephalitis in hamsters. American Journal of Pathology, 84(2), 351-370.

Lymphoreticular and myeloid pathogenesis of Venezuelan equine encephalitis in hamsters. / Walker, David; Harrison, A.; Murphy, K.; Flemister, M.; Murphy, F. A.

In: American Journal of Pathology, Vol. 84, No. 2, 1976, p. 351-370.

Research output: Contribution to journalArticle

Walker, D, Harrison, A, Murphy, K, Flemister, M & Murphy, FA 1976, 'Lymphoreticular and myeloid pathogenesis of Venezuelan equine encephalitis in hamsters', American Journal of Pathology, vol. 84, no. 2, pp. 351-370.
Walker, David ; Harrison, A. ; Murphy, K. ; Flemister, M. ; Murphy, F. A. / Lymphoreticular and myeloid pathogenesis of Venezuelan equine encephalitis in hamsters. In: American Journal of Pathology. 1976 ; Vol. 84, No. 2. pp. 351-370.
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