Lymphotoxin-alpha deficiency completely protects C57BL/6 mice from developing clinical experimental autoimmune myasthenia gravis

Elzbieta Goluszko, Peter Hjelmström, Caishu Deng, Mathilde A. Poussin, Nancy H. Ruddle, Premkumar Christadoss

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A complete prevention of clinical experimental autoimmune myasthenia gravis (EAMG) was observed in lymphotoxin (LT)-α deficient (LT-α-/-) mice compared to LT-α+/+ mice when immunized with acetylcholine receptor. However, only a partial prevention of clinical EAMG incidence was observed in LT-β-/- mice compared to LT-β+/+ mice. LT-α-/- and LT-β-/- mice had lower mean titers of total IgG, IgG1, IgG2a and IgG2b and higher or equal mean titers of IgM anti-AChR antibodies compared to controls. Therefore, LT-α-/- and LT-β-/- AChR immunized mice are capable of mounting a primary (IgM) humoral immune response to AChR, but are less capable of switching to the pathogenic anti-AChR IgG isotypes. LT could play a significant role in the pathogenesis of myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalJournal of Neuroimmunology
Volume113
Issue number1
DOIs
StatePublished - Feb 1 2001

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Autoimmune Experimental Myasthenia Gravis
Lymphotoxin-alpha
Inbred C57BL Mouse
Immunoglobulin M
Immunoglobulin G
Myasthenia Gravis
Cholinergic Receptors
Humoral Immunity
Anti-Idiotypic Antibodies

Keywords

  • Acetylcholine receptors
  • Autoimmunity
  • Cytokines
  • Lymphotoxins
  • Myasthenia gravis
  • TNF receptors

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Lymphotoxin-alpha deficiency completely protects C57BL/6 mice from developing clinical experimental autoimmune myasthenia gravis. / Goluszko, Elzbieta; Hjelmström, Peter; Deng, Caishu; Poussin, Mathilde A.; Ruddle, Nancy H.; Christadoss, Premkumar.

In: Journal of Neuroimmunology, Vol. 113, No. 1, 01.02.2001, p. 109-118.

Research output: Contribution to journalArticle

Goluszko, Elzbieta ; Hjelmström, Peter ; Deng, Caishu ; Poussin, Mathilde A. ; Ruddle, Nancy H. ; Christadoss, Premkumar. / Lymphotoxin-alpha deficiency completely protects C57BL/6 mice from developing clinical experimental autoimmune myasthenia gravis. In: Journal of Neuroimmunology. 2001 ; Vol. 113, No. 1. pp. 109-118.
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