Lyssavirus infection of muscle spindles and motor end plates in striated muscle of hamsters

Alyne K. Harrison, F. A. Murphy

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Immunofluorescent, light, and electron microscopy were used to document lyssavirus infection of muscle spindles and motor end plates. Virus particles were seen in the narrow intercellular space between sensory nerve endings and intrafusal muscle fibers; they were also observed budding from intracellular and plasma membranes of the latter. Involvement of motor nerves and motor end plates could only be demonstrated by electron microscopy. In nature, rabies virus invasion of the peripheral nervous system must involve centripetal spread across these junctions.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalArchives of virology
Volume57
Issue number2
DOIs
StatePublished - Jun 1 1978

ASJC Scopus subject areas

  • Virology

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