Macaque model for severe acute respiratory syndrome

Thomas Rowe, Guangping Gao, Robert J. Hogan, Ronald G. Crystal, Thomas G. Voss, Rebecca L. Grant, Peter Bell, Gary P. Kobinger, Nelson A. Wivel, James M. Wilson

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

Rhesus and cynomolgus macaques were challenged with 107 PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.

Original languageEnglish (US)
Pages (from-to)11401-11404
Number of pages4
JournalJournal of virology
Volume78
Issue number20
DOIs
StatePublished - Oct 2004
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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