Macrophage migration inhibitory factor down-regulates the RANKL-RANK signaling pathway by activating lyn tyrosine kinase in mouse models

Biochemistry, Genetics and Molecular Biology

• Mouse Model 100%
• Signal Transduction 100%
• Receptor Tyrosine Kinase 100%
• Tyrosine Kinase 100%
• CD74 100%
• Macrophage Migration Inhibitory Factor 100%
• Osteoclastogenesis 100%
• RANKL 100%
• RANK 100%
• Knockout Mouse 75%
• Downregulation 75%
• CD44 75%
• Small Interfering RNA 50%
• AP-1 Transcription Factor 50%
• Protein Expression 25%
• Immunoprecipitation 25%
• Innate Immunity 25%
• Adaptive Immunity 25%
• Cell Surface Protein 25%
• Syk 25%
• Calcium Signaling 25%
• Western Blotting 25%
• Lecithinase 25%

Keyphrases

• Mouse Model 100%
• Macrophage Migration Inhibitory Factor 100%
• Migration Inhibitory Factor 100%
• Lyn Tyrosine Kinase 100%
• Receptor Activator of nuclear factor-κB Ligand (RANKL) 100%
• RANK Signaling Pathways 100%
• Osteoclastogenesis 50%
• CD74 50%
• Cluster of Differentiation 44 (CD44) 37%
• KO Mice 37%
• Small Interfering RNA (siRNA) 25%
• Activator protein-1 (AP-1) 25%
• Co-receptor 25%
• Co-immunoprecipitation (co-IP) 12%
• Innate Immunity 12%
• Protein Expression 12%
• Phosphorylation 12%
• Western Blot Analysis 12%
• Surface Proteins 12%
• Adaptive Immunity 12%
• Signaling Cascades 12%
• Tyrosine Kinase 12%
• Phospholipase C 12%
• Local Inflammatory Response 12%
• Calcium Signaling 12%
• Real-time Imaging 12%
• Signal Component 12%

Neuroscience

• Cell Signaling 100%
• Protein Kinase Lyn 100%
• Macrophage Migration Inhibition Factor 100%
• Migration Inhibition Factor 100%
• RANKL 100%
• RANK 100%
• CD44 37%
• Receptor 37%
• Small Interfering RNA 25%
• AP-1 Transcription Factor 25%
• Immunoprecipitation 12%
• Protein Expression 12%
• Calcium Signaling 12%
• Adaptive Immunity 12%
• Western Blotting 12%
• Lecithinase 12%