Our goal was to analyze the changes in morphology and physiological function (phagocytosis, migratory capabilities, humoral and cellular response, and nitric oxide secretion) of murine macrophages after labeling with a clinically used superparamagnetic iron oxide (SPIO), ferucarbotran. In SPIO-treated macrophages, nanoparticles were taken up in the cytoplasm and accumulated in a membrane-bound organelle. Macrophage proliferation and viability were not modified after SPIO labeling. Phagocytic function decreased after labeling with only 10 μg Fe/mL. SPIO, whereas other functions including migration and production of tumor necrosis factor-α and nitric oxide increased at the highest SPIO concentration (100 μg Fe/mL).
- Iron oxide
- Rumor necrosis factor
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
Macrophage physiological function after superparamagnetic iron oxide labeling. / Hsiao, Jong Kai; Chu, Hung Hao; Wang, Yu Hsiu; Lai, Chih Wei; Chou, Pi Tai; Hsieh, Sung Tsang; Wang, Jaw Lin; Liu, Hon Man.In: NMR in Biomedicine, Vol. 21, No. 8, 01.10.2008, p. 820-829.
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