■ BACKGROUND AND OBJECTIVE: Wavefront analysis aims to measure aberrations in the eye, often before and after surgeries. The Hartmann-Shack instrument is an outgoing reflective aberrometer that uses a laser light source. The authors aimed to evaluate changes in aberrations of the eyes with macular irregularity by comparing with the fellow normal eyes. ■ PATIENTS AND METHODS: In a prospective study, the authors evaluated both eyes of patients with unilateral acquired foveal lesion by ZyWave (ZyWave; Milwaukee, WI) aberrometer. Eighteen eyes of 9 patients with a mean age of 32 years were examined. ■ RESULTS: After exclusion of two cases with central serous chorioretinopathy (due to smooth macular surface), a statistically significant increase in higher-order aberration in the involved eyes compared with the normal fellow eyes (P = .043) was found. There was also a statistically significant increase in horizontal trefoil in the involved eyes compared with normal eyes (P = .04). ■ CONCLUSION: This fellow eye study shows that macular irregularity might increase high-order aberrations measured by the Hartmann-Shack aberrometer.
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