Macular pigment density and distribution: Comparison of fundus autofluorescence with minimum motion photometry

Anthony G. Robson; Jack D. Moreland; Daniel Pauleikhoff; Tony Morrissey; Graham E. Holder; Fred W. Fitzke; Alan C. Bird; Frederik J.G.M. Van Kuijk

doi:10.1016/S0042-6989(03)00280-3

Macular pigment density and distribution: Comparison of fundus autofluorescence with minimum motion photometry

Anthony G. Robson
, Jack D. Moreland
, Daniel Pauleikhoff
, Tony Morrissey
, Graham E. Holder
, Fred W. Fitzke
, Alan C. Bird
, Frederik J.G.M. Van Kuijk

Ophthalmology & Visual Sciences

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7° was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.

Original language	English (US)
Pages (from-to)	1765-1775
Number of pages	11
Journal	Vision Research
Volume	43
Issue number	16
DOIs	https://doi.org/10.1016/S0042-6989(03)00280-3
State	Published - Jul 2003

Keywords

Age-related macular degeneration
Autofluorescence
Imaging
Macular pigment
Motion photometry

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/S0042-6989(03)00280-3

Cite this

@article{5182c91fc7ae4f95869b0b30541b5016,

title = "Macular pigment density and distribution: Comparison of fundus autofluorescence with minimum motion photometry",

abstract = "Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7° was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.",

keywords = "Age-related macular degeneration, Autofluorescence, Imaging, Macular pigment, Motion photometry",

author = "Robson, \{Anthony G.\} and Moreland, \{Jack D.\} and Daniel Pauleikhoff and Tony Morrissey and Holder, \{Graham E.\} and Fitzke, \{Fred W.\} and Bird, \{Alan C.\} and \{Van Kuijk\}, \{Frederik J.G.M.\}",

year = "2003",

month = jul,

doi = "10.1016/S0042-6989(03)00280-3",

language = "English (US)",

volume = "43",

pages = "1765--1775",

journal = "Vision Research",

issn = "0042-6989",

publisher = "Elsevier Ltd",

number = "16",

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TY - JOUR

T1 - Macular pigment density and distribution

T2 - Comparison of fundus autofluorescence with minimum motion photometry

AU - Robson, Anthony G.

AU - Moreland, Jack D.

AU - Pauleikhoff, Daniel

AU - Morrissey, Tony

AU - Holder, Graham E.

AU - Fitzke, Fred W.

AU - Bird, Alan C.

AU - Van Kuijk, Frederik J.G.M.

PY - 2003/7

Y1 - 2003/7

N2 - Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7° was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.

AB - Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7° was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.

KW - Age-related macular degeneration

KW - Autofluorescence

KW - Imaging

KW - Macular pigment

KW - Motion photometry

UR - https://www.scopus.com/pages/publications/0038345865

UR - https://www.scopus.com/pages/publications/0038345865#tab=citedBy

U2 - 10.1016/S0042-6989(03)00280-3

DO - 10.1016/S0042-6989(03)00280-3

M3 - Article

C2 - 12818346

AN - SCOPUS:0038345865

SN - 0042-6989

VL - 43

SP - 1765

EP - 1775

JO - Vision Research

JF - Vision Research

IS - 16

ER -

Macular pigment density and distribution: Comparison of fundus autofluorescence with minimum motion photometry

Abstract

Keywords

ASJC Scopus subject areas

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