Magnesium sulfate pharmacokinetics

Pregnant capra hircus model

Gary Hankins, Russell Snyder, J. C. Hauth, L. C. Gilstrap, F. H. Wians, A. F. Van Dellen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A comparison of standard clinical regimens for the administration of magnesium sulfate for treatment of preeclampsia was performed in the pregnant goat model. The regimen of intravenous or intramuscular load and intramuscular maintenance championed by Pritchard was found to yield higher maternal serum levels through the first 4 hours of treatment compared with intravenous load with intravenous maintenance therapy (p < 0.05); however, neither regimen affected the concentration of magnesium ion in the cerebrospinal fluid. Urinary excretion of magnesium and passage into the amniotic fluid were also evaluated for each route of administration and neither accounted for the disparity in serum concentrations noted during the first 4 hours of magnesium therapy.

Original languageEnglish (US)
Pages (from-to)49-53
Number of pages5
JournalAmerican Journal of Perinatology
Volume7
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Magnesium Sulfate
Goats
Magnesium
Pharmacokinetics
Amniotic Fluid
Pre-Eclampsia
Serum
Cerebrospinal Fluid
Maintenance
Mothers
Ions
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Hankins, G., Snyder, R., Hauth, J. C., Gilstrap, L. C., Wians, F. H., & Van Dellen, A. F. (1990). Magnesium sulfate pharmacokinetics: Pregnant capra hircus model. American Journal of Perinatology, 7(1), 49-53.

Magnesium sulfate pharmacokinetics : Pregnant capra hircus model. / Hankins, Gary; Snyder, Russell; Hauth, J. C.; Gilstrap, L. C.; Wians, F. H.; Van Dellen, A. F.

In: American Journal of Perinatology, Vol. 7, No. 1, 1990, p. 49-53.

Research output: Contribution to journalArticle

Hankins, G, Snyder, R, Hauth, JC, Gilstrap, LC, Wians, FH & Van Dellen, AF 1990, 'Magnesium sulfate pharmacokinetics: Pregnant capra hircus model', American Journal of Perinatology, vol. 7, no. 1, pp. 49-53.
Hankins G, Snyder R, Hauth JC, Gilstrap LC, Wians FH, Van Dellen AF. Magnesium sulfate pharmacokinetics: Pregnant capra hircus model. American Journal of Perinatology. 1990;7(1):49-53.
Hankins, Gary ; Snyder, Russell ; Hauth, J. C. ; Gilstrap, L. C. ; Wians, F. H. ; Van Dellen, A. F. / Magnesium sulfate pharmacokinetics : Pregnant capra hircus model. In: American Journal of Perinatology. 1990 ; Vol. 7, No. 1. pp. 49-53.
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