Maguari virus associated with human disease

Allison Groseth, Veronica Vine, Carla Weisend, Carolina Guevara, Douglas Watts, Brandy Russell, Robert B. Tesh, Hideki Ebihara

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Despite the lack of evidence for symptomatic human infection with Maguari virus (MAGV), its close relation to Cache Valley virus (CVV), which does infect humans, remains a concern. We sequenced the complete genome of a MAGV-like isolate (OBS6657) obtained from a febrile patient in Pucallpa, Ucayali, Peru, in 1998. To facilitate its classification, we generated additional full-length sequences for the MAGV prototype strain, 3 additional MAGV-like isolates, and the closely related CVV (7 strains), Tlacotalpan (1 strain), Playas (3 strains), and Fort Sherman (1 strain) viruses. The OBS6657 isolate is similar to the MAGV prototype, whereas 2 of the other MAGV-like isolates are located on a distinct branch and most likely warrant classification as a separate virus species and 1 is, in fact, a misclassified CVV strain. Our findings provide clear evidence that MAGV can cause human disease.

Original languageEnglish (US)
Pages (from-to)1325-1331
Number of pages7
JournalEmerging Infectious Diseases
Volume23
Issue number8
DOIs
StatePublished - Aug 1 2017

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Viruses
Bunyamwera virus
Peru
Fever
Genome
Infection

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Groseth, A., Vine, V., Weisend, C., Guevara, C., Watts, D., Russell, B., ... Ebihara, H. (2017). Maguari virus associated with human disease. Emerging Infectious Diseases, 23(8), 1325-1331. https://doi.org/10.3201/eid2308.161254

Maguari virus associated with human disease. / Groseth, Allison; Vine, Veronica; Weisend, Carla; Guevara, Carolina; Watts, Douglas; Russell, Brandy; Tesh, Robert B.; Ebihara, Hideki.

In: Emerging Infectious Diseases, Vol. 23, No. 8, 01.08.2017, p. 1325-1331.

Research output: Contribution to journalArticle

Groseth, A, Vine, V, Weisend, C, Guevara, C, Watts, D, Russell, B, Tesh, RB & Ebihara, H 2017, 'Maguari virus associated with human disease', Emerging Infectious Diseases, vol. 23, no. 8, pp. 1325-1331. https://doi.org/10.3201/eid2308.161254
Groseth A, Vine V, Weisend C, Guevara C, Watts D, Russell B et al. Maguari virus associated with human disease. Emerging Infectious Diseases. 2017 Aug 1;23(8):1325-1331. https://doi.org/10.3201/eid2308.161254
Groseth, Allison ; Vine, Veronica ; Weisend, Carla ; Guevara, Carolina ; Watts, Douglas ; Russell, Brandy ; Tesh, Robert B. ; Ebihara, Hideki. / Maguari virus associated with human disease. In: Emerging Infectious Diseases. 2017 ; Vol. 23, No. 8. pp. 1325-1331.
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