Major depression and anxiety disorders associated with Norplant

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Norplant is a relatively new long-acting subdermal implant system that is used widely for contraception. In a recent report, Wagner and Berenson described two cases of Norplant-associated major depression and panic disorder. These were the first reports of severe psychiatric disorders linked to the use of Norplant. Method: Five cases are described of women who developed major depression, two of whom also developed obsessive-compulsive disorder and one of whom also developed agoraphobia, while using the Norplant system. Results: These women who had no prior psychiatric history developed major depression within 1 to 3 months after Norplant insertion. The depression worsened over time and in all cases resolved within 1 to 2 months after Norplant removal. There was no recurrence of depression after 7 to 8 months in four cases available for follow-up. In addition to major depression, obsessive-compulsive disorder developed in two women and symptoms of agorapbobia developed in one woman during Norplant treatment, which resolved after Norplant removal. Conclusion: These cases provide further support for the association between Norplant and major depression, as well as a broad spectrum of anxiety disorders. It is important to design prospective studies to carefully examine the incidence of major depression and anxiety disorders in women who use Norplant. Risk factors for these disorders require further clarification.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalJournal of Clinical Psychiatry
Volume57
Issue number4
StatePublished - Apr 1996

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Levonorgestrel
Anxiety Disorders
Depression
Obsessive-Compulsive Disorder
Psychiatry
Agoraphobia
Panic Disorder
Contraception
Prospective Studies
Recurrence

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Major depression and anxiety disorders associated with Norplant. / Wagner, Karen.

In: Journal of Clinical Psychiatry, Vol. 57, No. 4, 04.1996, p. 152-157.

Research output: Contribution to journalArticle

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