Malakal virus from Africa and Kimberley virus from Australia are geographic variants of a widely distributed ephemerovirus

Kim R. Blasdell, Rhonda Voysey, Dieter M. Bulach, Lee Trinidad, Robert B. Tesh, David B. Boyle, Peter J. Walker

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Kimberley virus (KIMV) is an arthropod-borne rhabdovirus that was isolated in 1973 and on several subsequent occasions from healthy cattle, mosquitoes (Culex annulirostris) and biting midges (Culicoides brevitarsis) in Australia. Malakal virus (MALV) is an antigenically related rhabdovirus isolated in 1963 from mosquitoes (Mansonia uniformis) in Sudan. We report here the complete genome sequences of KIMV (15442 nt) and MALV (15444 nt). The genomes have a similar organisation (3'-l-N-P-M-G-GNS-α1-α2-Β-γ-L-t-5') to that of bovine ephemeral fever virus (BEFV). High levels of amino acid identity in each gene, similar gene expression profiles, clustering in phylogenetic analyses of the N, P, G and L proteins, and strong cross-neutralisation indicate that KIMV and MALV are geographic variants of the same ephemerovirus that, like BEFV, occurs in Africa, Asia and Australia.

Original languageEnglish
Pages (from-to)236-244
Number of pages9
JournalVirology
Volume433
Issue number1
DOIs
StatePublished - Nov 10 2012

Fingerprint

Ephemerovirus
Bovine ephemeral fever virus
Viruses
Rhabdoviridae
Ceratopogonidae
Culicidae
Sterculiaceae
Genome
Arboviruses
Culex
Sudan
Transcriptome
Cluster Analysis
Amino Acids

Keywords

  • Ephemerovirus
  • Gene expression
  • Genome sequence
  • Kimberley virus
  • Malakal virus
  • Rhabdovirus

ASJC Scopus subject areas

  • Virology

Cite this

Blasdell, K. R., Voysey, R., Bulach, D. M., Trinidad, L., Tesh, R. B., Boyle, D. B., & Walker, P. J. (2012). Malakal virus from Africa and Kimberley virus from Australia are geographic variants of a widely distributed ephemerovirus. Virology, 433(1), 236-244. https://doi.org/10.1016/j.virol.2012.08.008

Malakal virus from Africa and Kimberley virus from Australia are geographic variants of a widely distributed ephemerovirus. / Blasdell, Kim R.; Voysey, Rhonda; Bulach, Dieter M.; Trinidad, Lee; Tesh, Robert B.; Boyle, David B.; Walker, Peter J.

In: Virology, Vol. 433, No. 1, 10.11.2012, p. 236-244.

Research output: Contribution to journalArticle

Blasdell, KR, Voysey, R, Bulach, DM, Trinidad, L, Tesh, RB, Boyle, DB & Walker, PJ 2012, 'Malakal virus from Africa and Kimberley virus from Australia are geographic variants of a widely distributed ephemerovirus', Virology, vol. 433, no. 1, pp. 236-244. https://doi.org/10.1016/j.virol.2012.08.008
Blasdell, Kim R. ; Voysey, Rhonda ; Bulach, Dieter M. ; Trinidad, Lee ; Tesh, Robert B. ; Boyle, David B. ; Walker, Peter J. / Malakal virus from Africa and Kimberley virus from Australia are geographic variants of a widely distributed ephemerovirus. In: Virology. 2012 ; Vol. 433, No. 1. pp. 236-244.
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