Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi

A. H. Achtman, Robin Stephens, E. T. Cadman, V. Harrison, J. Langhorne

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

While it is known that antibodies are critical for clearance of malaria infections, it is not clear whether adequate antibody responses are maintained and what effect chronic infection has on this response. Here we show that mice with low-grade chronic primary infections of Plasmodium chabaudi or infections very recently eliminated have reduced second infections when compared with the second infection of parasite-free mice. We also show that parasite-specific antibody responses induced by infection of mice with Plasmodium chabaudi contain both short- and long-lived components as well as memory B cells responsible for a faster antibody response during re-infection. Furthermore, parasite-specific antibodies to the C-terminal fragment of merozoite surface protein-1 (MSP-1) undergo avidity maturation. However, antibodies with both low and high avidity persist throughout infection and after re-infection, suggesting repeated rounds of activation and maturation of memory B cells. Neither the avidity profile of the antibody response, nor its maintenance is affected by persisting live parasites. Therefore, differences in parasitemia in re-infection cannot be explained solely by higher levels of antibody or greater affinity maturation of malaria-specific antibodies. These data suggest that there may be an antibody-independent component to the early control of secondary infections in mice that are chronically infected.

Original languageEnglish (US)
Pages (from-to)435-444
Number of pages10
JournalParasite Immunology
Volume29
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

Fingerprint

Plasmodium chabaudi
Malaria
Antibody Formation
Parasites
Infection
Antibodies
B-Lymphocytes
Merozoite Surface Protein 1
Parasitic Diseases
Parasitemia
Coinfection

Keywords

  • Antibody response
  • Avidity
  • Chloroquine
  • Malaria
  • Plasmodium chabaudi

ASJC Scopus subject areas

  • Parasitology
  • Immunology

Cite this

Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi. / Achtman, A. H.; Stephens, Robin; Cadman, E. T.; Harrison, V.; Langhorne, J.

In: Parasite Immunology, Vol. 29, No. 9, 09.2007, p. 435-444.

Research output: Contribution to journalArticle

Achtman, A. H. ; Stephens, Robin ; Cadman, E. T. ; Harrison, V. ; Langhorne, J. / Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi. In: Parasite Immunology. 2007 ; Vol. 29, No. 9. pp. 435-444.
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