Malignant hyperthermia susceptibility. A light and electron microscopic study of endomyocardial biopsy specimens from nine patients

Nobby Mambo, Malcolm D. Silver, Peter R. McLaughlin, Victor F. Huckell, Patricia M. McEwan, Beverly A. Britt, John E. Morch

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cardiomyopathy develops in some individuals who have a susceptibility to malignant hyperthermia. We studied right ventricular endomyocardial biopsy specimens from nine patients defined as having this disorder because of positive caffeine contracture tests on skeletal muscle biopsy specimens. Three patients had clinical evidence of cardiomyopathy and six did not. Light microscopy showed cytoplasmic contraction bands, perinuclear clearing, and a mild to moderate variation in myocyte and nuclear size. Ultrastructurally cytoplasmic contraction bands were associated with cardiac villi, myofiberlysis, and myofibrillolysis. These changes and occasional breaks in the sarcolemma were regarded as artefacts of the biopsy procedure. Megamitochondriosis with accompanying degenerative changes in the mitochondria were also seen and probably indicate increased cell metabolism; vacuolation of the cytoplasm was regarded as an "aging" phenomenon. Thus, the biopsy specimens were abnormal, but the changes were artefactual or nonspecific and were not unique to this group of patients. Biopsy did not provide a morphological explanation for abnormal cardiac function.

Original languageEnglish (US)
Pages (from-to)381-388
Number of pages8
JournalHuman Pathology
Volume11
Issue number4
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Malignant Hyperthermia
Electrons
Biopsy
Light
Cardiomyopathies
Sarcolemma
Contracture
Caffeine
Artifacts
Muscle Cells
Microscopy
Mitochondria
Cytoplasm
Skeletal Muscle

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Mambo, N., Silver, M. D., McLaughlin, P. R., Huckell, V. F., McEwan, P. M., Britt, B. A., & Morch, J. E. (1980). Malignant hyperthermia susceptibility. A light and electron microscopic study of endomyocardial biopsy specimens from nine patients. Human Pathology, 11(4), 381-388. https://doi.org/10.1016/S0046-8177(80)80036-0

Malignant hyperthermia susceptibility. A light and electron microscopic study of endomyocardial biopsy specimens from nine patients. / Mambo, Nobby; Silver, Malcolm D.; McLaughlin, Peter R.; Huckell, Victor F.; McEwan, Patricia M.; Britt, Beverly A.; Morch, John E.

In: Human Pathology, Vol. 11, No. 4, 1980, p. 381-388.

Research output: Contribution to journalArticle

Mambo, Nobby ; Silver, Malcolm D. ; McLaughlin, Peter R. ; Huckell, Victor F. ; McEwan, Patricia M. ; Britt, Beverly A. ; Morch, John E. / Malignant hyperthermia susceptibility. A light and electron microscopic study of endomyocardial biopsy specimens from nine patients. In: Human Pathology. 1980 ; Vol. 11, No. 4. pp. 381-388.
@article{47dfc9cd8cc24d8598c04fc4a9ff88b3,
title = "Malignant hyperthermia susceptibility. A light and electron microscopic study of endomyocardial biopsy specimens from nine patients",
abstract = "Cardiomyopathy develops in some individuals who have a susceptibility to malignant hyperthermia. We studied right ventricular endomyocardial biopsy specimens from nine patients defined as having this disorder because of positive caffeine contracture tests on skeletal muscle biopsy specimens. Three patients had clinical evidence of cardiomyopathy and six did not. Light microscopy showed cytoplasmic contraction bands, perinuclear clearing, and a mild to moderate variation in myocyte and nuclear size. Ultrastructurally cytoplasmic contraction bands were associated with cardiac villi, myofiberlysis, and myofibrillolysis. These changes and occasional breaks in the sarcolemma were regarded as artefacts of the biopsy procedure. Megamitochondriosis with accompanying degenerative changes in the mitochondria were also seen and probably indicate increased cell metabolism; vacuolation of the cytoplasm was regarded as an {"}aging{"} phenomenon. Thus, the biopsy specimens were abnormal, but the changes were artefactual or nonspecific and were not unique to this group of patients. Biopsy did not provide a morphological explanation for abnormal cardiac function.",
author = "Nobby Mambo and Silver, {Malcolm D.} and McLaughlin, {Peter R.} and Huckell, {Victor F.} and McEwan, {Patricia M.} and Britt, {Beverly A.} and Morch, {John E.}",
year = "1980",
doi = "10.1016/S0046-8177(80)80036-0",
language = "English (US)",
volume = "11",
pages = "381--388",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Malignant hyperthermia susceptibility. A light and electron microscopic study of endomyocardial biopsy specimens from nine patients

AU - Mambo, Nobby

AU - Silver, Malcolm D.

AU - McLaughlin, Peter R.

AU - Huckell, Victor F.

AU - McEwan, Patricia M.

AU - Britt, Beverly A.

AU - Morch, John E.

PY - 1980

Y1 - 1980

N2 - Cardiomyopathy develops in some individuals who have a susceptibility to malignant hyperthermia. We studied right ventricular endomyocardial biopsy specimens from nine patients defined as having this disorder because of positive caffeine contracture tests on skeletal muscle biopsy specimens. Three patients had clinical evidence of cardiomyopathy and six did not. Light microscopy showed cytoplasmic contraction bands, perinuclear clearing, and a mild to moderate variation in myocyte and nuclear size. Ultrastructurally cytoplasmic contraction bands were associated with cardiac villi, myofiberlysis, and myofibrillolysis. These changes and occasional breaks in the sarcolemma were regarded as artefacts of the biopsy procedure. Megamitochondriosis with accompanying degenerative changes in the mitochondria were also seen and probably indicate increased cell metabolism; vacuolation of the cytoplasm was regarded as an "aging" phenomenon. Thus, the biopsy specimens were abnormal, but the changes were artefactual or nonspecific and were not unique to this group of patients. Biopsy did not provide a morphological explanation for abnormal cardiac function.

AB - Cardiomyopathy develops in some individuals who have a susceptibility to malignant hyperthermia. We studied right ventricular endomyocardial biopsy specimens from nine patients defined as having this disorder because of positive caffeine contracture tests on skeletal muscle biopsy specimens. Three patients had clinical evidence of cardiomyopathy and six did not. Light microscopy showed cytoplasmic contraction bands, perinuclear clearing, and a mild to moderate variation in myocyte and nuclear size. Ultrastructurally cytoplasmic contraction bands were associated with cardiac villi, myofiberlysis, and myofibrillolysis. These changes and occasional breaks in the sarcolemma were regarded as artefacts of the biopsy procedure. Megamitochondriosis with accompanying degenerative changes in the mitochondria were also seen and probably indicate increased cell metabolism; vacuolation of the cytoplasm was regarded as an "aging" phenomenon. Thus, the biopsy specimens were abnormal, but the changes were artefactual or nonspecific and were not unique to this group of patients. Biopsy did not provide a morphological explanation for abnormal cardiac function.

UR - http://www.scopus.com/inward/record.url?scp=0018952679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018952679&partnerID=8YFLogxK

U2 - 10.1016/S0046-8177(80)80036-0

DO - 10.1016/S0046-8177(80)80036-0

M3 - Article

VL - 11

SP - 381

EP - 388

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 4

ER -