Mammalian DNA base excision repair proteins

Their interactions and role in repair of oxidative DNA damage

Tadahide Izumi, Lee Wiederhold, Gargi Roy, Rabindra Roy, Arun Jaiswal, Kishor K. Bhakat, Sankar Mitra, Tapas Hazra

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions.

Original languageEnglish (US)
Pages (from-to)43-65
Number of pages23
JournalToxicology
Volume193
Issue number1-2
DOIs
StatePublished - Nov 15 2003

Fingerprint

DNA Repair
DNA Damage
Repair
DNA
Proteins
Chemical reactions
Reactive Oxygen Species
Genes
Genome

Keywords

  • Base excision repair
  • DNA
  • Reactive oxygen species

ASJC Scopus subject areas

  • Toxicology

Cite this

Mammalian DNA base excision repair proteins : Their interactions and role in repair of oxidative DNA damage. / Izumi, Tadahide; Wiederhold, Lee; Roy, Gargi; Roy, Rabindra; Jaiswal, Arun; Bhakat, Kishor K.; Mitra, Sankar; Hazra, Tapas.

In: Toxicology, Vol. 193, No. 1-2, 15.11.2003, p. 43-65.

Research output: Contribution to journalArticle

Izumi, T, Wiederhold, L, Roy, G, Roy, R, Jaiswal, A, Bhakat, KK, Mitra, S & Hazra, T 2003, 'Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage', Toxicology, vol. 193, no. 1-2, pp. 43-65. https://doi.org/10.1016/S0300-483X(03)00289-0
Izumi, Tadahide ; Wiederhold, Lee ; Roy, Gargi ; Roy, Rabindra ; Jaiswal, Arun ; Bhakat, Kishor K. ; Mitra, Sankar ; Hazra, Tapas. / Mammalian DNA base excision repair proteins : Their interactions and role in repair of oxidative DNA damage. In: Toxicology. 2003 ; Vol. 193, No. 1-2. pp. 43-65.
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