Management of hepatic metastasis from colorectal cancers: An update

Sharad Sharma, Cemalettin Camci, Nicolas Jabbour

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Approximately 50%-60% of patients with colorectal cancers will develop liver lesions in their life span. Despite the potential of surgical resection to provide long-term survival in this subset of patients, only 15%-20% are found to be resectable. The introduction of new neoadjuvant chemotherapeutic agents and the expanding criteria of resection have enhanced the overall 5-year survival from 30% to 60% in the past decade. The use of technical innovations such as staged resection; portal vein embolization, and repeat resection have allowed higher resection rates in patients with bilobar disease. Extrahepatic primary and liver-exclusive recurrent disease no longer represent an absolute contraindication to resection. The role of regional therapy using hepatic arterial infusion is being redefined for liver-exclusive unresectable disease. Adjuvant chemotherapy in combination with regional therapies is being looked at from fresh perspectives. Ablative approaches have gained a firm role both as an adjunct to surgical resection and in the management of patients who are not surgical candidates. Overall, the management of hepatic metastasis from colorectal cancers requires a multimodal approach.

Original languageEnglish (US)
Pages (from-to)570-580
Number of pages11
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume15
Issue number6
DOIs
StatePublished - Nov 21 2008
Externally publishedYes

Keywords

  • Cancer
  • Colorectal
  • Hepatic
  • Metastasis

ASJC Scopus subject areas

  • Surgery
  • Hepatology

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