Abstract
Pituitary gigantism, a condition of endogenous growth hormone (GH) hypersecretion prior to epiphyseal closure, is a rare condition. In the adult condition of GH excess, acromegaly, the occurrence of type 2 diabetes mellitus (T2DM) and diabetic ketoacidosis (DKA) have been reported, with resolution following normalization of GH levels. We report the case of a 16-year-old male with pituitary gigantism due to a large invasive suprasellar adenoma who presented with T2DM and DKA. Despite surgical de-bulking, radiotherapy and medical treatment with cabergoline and pegvisomant, GH and insulin-like growth factor-I (IGF-I) levels remained elevated. However, the T2DM and recurrent DKA were successfully managed with metformin and low-dose glargine insulin, respectively. We review the pathophysiology of T2DM and DKA in growth hormone excess and available treatment options.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 359-364 |
| Number of pages | 6 |
| Journal | Pituitary |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2007 |
| Externally published | Yes |
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Keywords
- Diabetes mellitus
- Diabetic ketoacidosis
- Growth hormone
- Metformin
- Pituitary gigantism
ASJC Scopus subject areas
- Endocrinology
Cite this
Management of type 2 diabetes mellitus associated with pituitary gigantism. / Ali, Omar; Banerjee, Swati; Kelly, Daniel F.; Lee, Phillip.
In: Pituitary, Vol. 10, No. 4, 12.2007, p. 359-364.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Management of type 2 diabetes mellitus associated with pituitary gigantism
AU - Ali, Omar
AU - Banerjee, Swati
AU - Kelly, Daniel F.
AU - Lee, Phillip
PY - 2007/12
Y1 - 2007/12
N2 - Pituitary gigantism, a condition of endogenous growth hormone (GH) hypersecretion prior to epiphyseal closure, is a rare condition. In the adult condition of GH excess, acromegaly, the occurrence of type 2 diabetes mellitus (T2DM) and diabetic ketoacidosis (DKA) have been reported, with resolution following normalization of GH levels. We report the case of a 16-year-old male with pituitary gigantism due to a large invasive suprasellar adenoma who presented with T2DM and DKA. Despite surgical de-bulking, radiotherapy and medical treatment with cabergoline and pegvisomant, GH and insulin-like growth factor-I (IGF-I) levels remained elevated. However, the T2DM and recurrent DKA were successfully managed with metformin and low-dose glargine insulin, respectively. We review the pathophysiology of T2DM and DKA in growth hormone excess and available treatment options.
AB - Pituitary gigantism, a condition of endogenous growth hormone (GH) hypersecretion prior to epiphyseal closure, is a rare condition. In the adult condition of GH excess, acromegaly, the occurrence of type 2 diabetes mellitus (T2DM) and diabetic ketoacidosis (DKA) have been reported, with resolution following normalization of GH levels. We report the case of a 16-year-old male with pituitary gigantism due to a large invasive suprasellar adenoma who presented with T2DM and DKA. Despite surgical de-bulking, radiotherapy and medical treatment with cabergoline and pegvisomant, GH and insulin-like growth factor-I (IGF-I) levels remained elevated. However, the T2DM and recurrent DKA were successfully managed with metformin and low-dose glargine insulin, respectively. We review the pathophysiology of T2DM and DKA in growth hormone excess and available treatment options.
KW - Diabetes mellitus
KW - Diabetic ketoacidosis
KW - Growth hormone
KW - Metformin
KW - Pituitary gigantism
UR - http://www.scopus.com/inward/record.url?scp=36249004283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36249004283&partnerID=8YFLogxK
U2 - 10.1007/s11102-007-0060-8
DO - 10.1007/s11102-007-0060-8
M3 - Article
VL - 10
SP - 359
EP - 364
JO - Pituitary
JF - Pituitary
SN - 1386-341X
IS - 4
ER -