Management of uterine hyperstimulation with concomitant use of oxytocin and terbutaline

Luis Pacheco, Mitchell P. Rosen, Alffredo F. Gei, George Saade, Gary Hankins

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the efficacy of the concomitant use of subcutaneous terbutaline and oxytocin for the management of uterine hyperstimulation. Patients in active labor receiving intravenous oxytocin who developed uterine hyperstimulation were randomly assigned to receive either oxytocin discontinuation or administration of subcutaneous terbutaline while maintaining the oxytocin infusion. Time to resolution of hyperstimulation was the primaiy end point. Twenty-nine patients were enrolled. The most frequent types of hyperstimulation were tachysystole (26%) and mixed patterns (26%). Resolution time was significantly shorter in the combination therapy versus control (p = 0.002). Persistence of hyperstimulation 15 minutes after intervention was seen in 53% of the women in the control group versus 0% of the women in the study group. No significant differences were noted in the Apgar scores, rates of cesarean sections, or chorioamnionitis. In the management of uterine hyperstimulation, subcutaneous terbutaline without discontinuation of oxytocin is more effective than the traditional approach of oxytocin discontinuation.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalAmerican Journal of Perinatology
Volume23
Issue number6
DOIs
StatePublished - Aug 2006

Fingerprint

Terbutaline
Oxytocin
Chorioamnionitis
Apgar Score
Cesarean Section
Control Groups

Keywords

  • Labor augmentation
  • Oxytocin
  • Terbutaline
  • Uterine hyperstimulation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Management of uterine hyperstimulation with concomitant use of oxytocin and terbutaline. / Pacheco, Luis; Rosen, Mitchell P.; Gei, Alffredo F.; Saade, George; Hankins, Gary.

In: American Journal of Perinatology, Vol. 23, No. 6, 08.2006, p. 377-380.

Research output: Contribution to journalArticle

Pacheco, Luis ; Rosen, Mitchell P. ; Gei, Alffredo F. ; Saade, George ; Hankins, Gary. / Management of uterine hyperstimulation with concomitant use of oxytocin and terbutaline. In: American Journal of Perinatology. 2006 ; Vol. 23, No. 6. pp. 377-380.
@article{cbc37a2bb0ed4f188c9ee07f0f340972,
title = "Management of uterine hyperstimulation with concomitant use of oxytocin and terbutaline",
abstract = "The purpose of this study was to evaluate the efficacy of the concomitant use of subcutaneous terbutaline and oxytocin for the management of uterine hyperstimulation. Patients in active labor receiving intravenous oxytocin who developed uterine hyperstimulation were randomly assigned to receive either oxytocin discontinuation or administration of subcutaneous terbutaline while maintaining the oxytocin infusion. Time to resolution of hyperstimulation was the primaiy end point. Twenty-nine patients were enrolled. The most frequent types of hyperstimulation were tachysystole (26{\%}) and mixed patterns (26{\%}). Resolution time was significantly shorter in the combination therapy versus control (p = 0.002). Persistence of hyperstimulation 15 minutes after intervention was seen in 53{\%} of the women in the control group versus 0{\%} of the women in the study group. No significant differences were noted in the Apgar scores, rates of cesarean sections, or chorioamnionitis. In the management of uterine hyperstimulation, subcutaneous terbutaline without discontinuation of oxytocin is more effective than the traditional approach of oxytocin discontinuation.",
keywords = "Labor augmentation, Oxytocin, Terbutaline, Uterine hyperstimulation",
author = "Luis Pacheco and Rosen, {Mitchell P.} and Gei, {Alffredo F.} and George Saade and Gary Hankins",
year = "2006",
month = "8",
doi = "10.1055/s-2006-948223",
language = "English (US)",
volume = "23",
pages = "377--380",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers",
number = "6",

}

TY - JOUR

T1 - Management of uterine hyperstimulation with concomitant use of oxytocin and terbutaline

AU - Pacheco, Luis

AU - Rosen, Mitchell P.

AU - Gei, Alffredo F.

AU - Saade, George

AU - Hankins, Gary

PY - 2006/8

Y1 - 2006/8

N2 - The purpose of this study was to evaluate the efficacy of the concomitant use of subcutaneous terbutaline and oxytocin for the management of uterine hyperstimulation. Patients in active labor receiving intravenous oxytocin who developed uterine hyperstimulation were randomly assigned to receive either oxytocin discontinuation or administration of subcutaneous terbutaline while maintaining the oxytocin infusion. Time to resolution of hyperstimulation was the primaiy end point. Twenty-nine patients were enrolled. The most frequent types of hyperstimulation were tachysystole (26%) and mixed patterns (26%). Resolution time was significantly shorter in the combination therapy versus control (p = 0.002). Persistence of hyperstimulation 15 minutes after intervention was seen in 53% of the women in the control group versus 0% of the women in the study group. No significant differences were noted in the Apgar scores, rates of cesarean sections, or chorioamnionitis. In the management of uterine hyperstimulation, subcutaneous terbutaline without discontinuation of oxytocin is more effective than the traditional approach of oxytocin discontinuation.

AB - The purpose of this study was to evaluate the efficacy of the concomitant use of subcutaneous terbutaline and oxytocin for the management of uterine hyperstimulation. Patients in active labor receiving intravenous oxytocin who developed uterine hyperstimulation were randomly assigned to receive either oxytocin discontinuation or administration of subcutaneous terbutaline while maintaining the oxytocin infusion. Time to resolution of hyperstimulation was the primaiy end point. Twenty-nine patients were enrolled. The most frequent types of hyperstimulation were tachysystole (26%) and mixed patterns (26%). Resolution time was significantly shorter in the combination therapy versus control (p = 0.002). Persistence of hyperstimulation 15 minutes after intervention was seen in 53% of the women in the control group versus 0% of the women in the study group. No significant differences were noted in the Apgar scores, rates of cesarean sections, or chorioamnionitis. In the management of uterine hyperstimulation, subcutaneous terbutaline without discontinuation of oxytocin is more effective than the traditional approach of oxytocin discontinuation.

KW - Labor augmentation

KW - Oxytocin

KW - Terbutaline

KW - Uterine hyperstimulation

UR - http://www.scopus.com/inward/record.url?scp=33747620099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747620099&partnerID=8YFLogxK

U2 - 10.1055/s-2006-948223

DO - 10.1055/s-2006-948223

M3 - Article

VL - 23

SP - 377

EP - 380

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

IS - 6

ER -