Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis

Jing Li, Huibin Qi, Erdem Tüzün, Windy Allman, Vuslat Yilmaz, Shamsher S. Saini, Feza Deymeer, Güher Saruhan-Direskeneli, Premkumar Christadoss

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Classical complement pathway factor, C4 is required for experimental autoimmune myasthenia gravis (EAMG) pathogenesis. C4 is also a central component of the mannose binding lectin (MBL) pathway suggesting that this pathway might also be involved in MG pathogenesis. However, MBL gene deficient mice displayed intact anti-acetylcholine receptor (AChR)-immune response and neuromuscular junction (NMJ) IgG and complement accumulation following AChR-immunization. Moreover, no significant difference was observed between the serum MBL levels of 77 anti-AChR antibody positive generalized MG patients and 105 healthy controls. Therefore, MBL pathway does not play a role in EAMG/MG pathogenesis.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalJournal of Neuroimmunology
Volume208
Issue number1-2
DOIs
StatePublished - Mar 31 2009

Fingerprint

Mannose-Binding Lectin
Myasthenia Gravis
Cholinergic Receptors
Autoimmune Experimental Myasthenia Gravis
Classical Complement Pathway
Neuromuscular Junction
Immunization
Immunoglobulin G
Antibodies
Serum
Genes

Keywords

  • Autoimmunity
  • Complement
  • Lectin pathway
  • Mannose binding lectin
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Li, J., Qi, H., Tüzün, E., Allman, W., Yilmaz, V., Saini, S. S., ... Christadoss, P. (2009). Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis. Journal of Neuroimmunology, 208(1-2), 40-45. https://doi.org/10.1016/j.jneuroim.2008.12.013

Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis. / Li, Jing; Qi, Huibin; Tüzün, Erdem; Allman, Windy; Yilmaz, Vuslat; Saini, Shamsher S.; Deymeer, Feza; Saruhan-Direskeneli, Güher; Christadoss, Premkumar.

In: Journal of Neuroimmunology, Vol. 208, No. 1-2, 31.03.2009, p. 40-45.

Research output: Contribution to journalArticle

Li, J, Qi, H, Tüzün, E, Allman, W, Yilmaz, V, Saini, SS, Deymeer, F, Saruhan-Direskeneli, G & Christadoss, P 2009, 'Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis', Journal of Neuroimmunology, vol. 208, no. 1-2, pp. 40-45. https://doi.org/10.1016/j.jneuroim.2008.12.013
Li, Jing ; Qi, Huibin ; Tüzün, Erdem ; Allman, Windy ; Yilmaz, Vuslat ; Saini, Shamsher S. ; Deymeer, Feza ; Saruhan-Direskeneli, Güher ; Christadoss, Premkumar. / Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis. In: Journal of Neuroimmunology. 2009 ; Vol. 208, No. 1-2. pp. 40-45.
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