Maporal viral infection in the Syrian golden hamster

A model of hantavirus pulmonary syndrome

Mary Louise Milazzo, Eduardo Eyzaguirre, Claudia P. Molina, Charles F. Fulhorst

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Hantavirus pulmonary syndrome (HPS) is a severe and often fatal rodent-borne zoonosis. Maporal (MAP) virus is a newly discovered hantavirus that originally was isolated from an arboreal rice rat captured in central Venezuela. The results of this study indicate that MAP virus in the Syrian golden hamster (Mesocricetus auratus) can cause a disease that is clinically and pathologically remarkably similar to HPS. The similarities include the time course of clinical disease, presence of virus-specific IgG at the onset of clinical disease, subacute pneumonitis, rapid onset of diffuse alveolar edema in the absence of necrosis, hepatic-portal triaditis, mononuclear-cellular infiltrate in lung and liver, widespread distribution of hantaviral antigen in endothelial cells of the microvasculature of lung and other tissues, and variable lethality. These similarities suggest that the MAP virus-hamster system is a useful model for studies of the pathogenesis of HPS and for the evaluation of potential therapeutic agents.

Original languageEnglish (US)
Pages (from-to)1390-1395
Number of pages6
JournalJournal of Infectious Diseases
Volume186
Issue number10
DOIs
StatePublished - Nov 15 2002

Fingerprint

Hantavirus Pulmonary Syndrome
Mesocricetus
Virus Diseases
Viruses
Sigmodontinae
Hantavirus
Lung
Venezuela
Liver
Zoonoses
Microvessels
Cricetinae
Rodentia
Edema
Pneumonia
Necrosis
Endothelial Cells
Immunoglobulin G
Antigens
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Maporal viral infection in the Syrian golden hamster : A model of hantavirus pulmonary syndrome. / Milazzo, Mary Louise; Eyzaguirre, Eduardo; Molina, Claudia P.; Fulhorst, Charles F.

In: Journal of Infectious Diseases, Vol. 186, No. 10, 15.11.2002, p. 1390-1395.

Research output: Contribution to journalArticle

Milazzo, Mary Louise ; Eyzaguirre, Eduardo ; Molina, Claudia P. ; Fulhorst, Charles F. / Maporal viral infection in the Syrian golden hamster : A model of hantavirus pulmonary syndrome. In: Journal of Infectious Diseases. 2002 ; Vol. 186, No. 10. pp. 1390-1395.
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