Marburg and Ebola Virus Hemorrhagic Fevers

Thomas W. Geisbert; Raphael Dolin

doi:10.1016/B978-0-323-48255-4.00164-8

Marburg and Ebola Virus Hemorrhagic Fevers

Thomas W. Geisbert
, Raphael Dolin

Microbiology And Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Members of the filovirus genera, Ebolavirus and Marburgvirus, cause lethal hemorrhagic fever in humans and nonhuman primates, with case-fatality rates of up to 90%. Small filovirus outbreaks in humans have occurred sporadically, primarily in Central Africa, for more than 50 years; however, an unprecedented epidemic of Zaire ebolavirus involving more than 28,000 cases and 11,000 deaths occurred in West Africa in 2013-16. Currently, there are no approved vaccines or antivirals against filoviruses, although a vesicular stomatitis virus-based vaccine expressing the Zaire ebolavirus glycoprotein showed remarkable success in a ring-vaccination cluster-randomized trial in Guinea during the 2013-16 Ebola epidemic.

Original language	English (US)
Title of host publication	Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 9th Edition
Subtitle of host publication	Volume 1-2
Publisher	Elsevier
Pages	2138-2142.e2
Volume	2
ISBN (Electronic)	9780323482554
ISBN (Print)	9780323775564
DOIs	https://doi.org/10.1016/B978-0-323-48255-4.00164-8
State	Published - Jan 1 2019

Keywords

Ebola virus
Filoviridae
filovirus
hemorrhagic fever
Marburg virus
pathogenesis
treatment
vaccine

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-323-48255-4.00164-8

Cite this

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abstract = "Members of the filovirus genera, Ebolavirus and Marburgvirus, cause lethal hemorrhagic fever in humans and nonhuman primates, with case-fatality rates of up to 90\%. Small filovirus outbreaks in humans have occurred sporadically, primarily in Central Africa, for more than 50 years; however, an unprecedented epidemic of Zaire ebolavirus involving more than 28,000 cases and 11,000 deaths occurred in West Africa in 2013-16. Currently, there are no approved vaccines or antivirals against filoviruses, although a vesicular stomatitis virus-based vaccine expressing the Zaire ebolavirus glycoprotein showed remarkable success in a ring-vaccination cluster-randomized trial in Guinea during the 2013-16 Ebola epidemic.",

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AU - Dolin, Raphael

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AB - Members of the filovirus genera, Ebolavirus and Marburgvirus, cause lethal hemorrhagic fever in humans and nonhuman primates, with case-fatality rates of up to 90%. Small filovirus outbreaks in humans have occurred sporadically, primarily in Central Africa, for more than 50 years; however, an unprecedented epidemic of Zaire ebolavirus involving more than 28,000 cases and 11,000 deaths occurred in West Africa in 2013-16. Currently, there are no approved vaccines or antivirals against filoviruses, although a vesicular stomatitis virus-based vaccine expressing the Zaire ebolavirus glycoprotein showed remarkable success in a ring-vaccination cluster-randomized trial in Guinea during the 2013-16 Ebola epidemic.

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KW - Filoviridae

KW - filovirus

KW - hemorrhagic fever

KW - Marburg virus

KW - pathogenesis

KW - treatment

KW - vaccine

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M3 - Chapter

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SN - 9780323775564

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BT - Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 9th Edition

PB - Elsevier

ER -

Marburg and Ebola Virus Hemorrhagic Fevers

Abstract

Keywords

ASJC Scopus subject areas

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