@article{efcbfd3ecac74811b6e7e2bd2aced6ec,
title = "Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets",
abstract = "Ferrets are used for studying infections with wild-type Ebola virus isolates. Here, we investigated whether these animals are also susceptible to wild-type isolates of Marburg virus (MARV). Ferrets were challenged intramuscularly or intranasally with MARV strain Angola and monitored for 3 weeks. Unexpectedly, the animals neither showed observable signs of disease nor died of infection, and viremia was not detected after challenge. All animals were seropositive for MARV-specific immunoglobulin antibodies. Confirmatory studies with MARV strain Musoke and Ravn virus yielded the same outcomes. Therefore, ferrets may be of limited usefulness for studying the pathogenesis of MARV and Ravn virus infections.",
keywords = "Marburg virus, Ravn virus, animal models, experimental infection., ferrets, pathogenesis",
author = "Gary Wong and Zirui Zhang and Shihua He and {De La Vega}, {Marc Antoine} and Kevin Tierney and Geoff Soule and Kaylie Tran and Lisa Fernando and Xiangguo Qiu",
note = "Funding Information: Financial support. This work was supported by the National Key Research and Development Program of China (2016YFE0205800), the National Key Program for Infectious Disease of China (2016ZX10004222), the Public Health Agency of Canada, the National Institutes of Health (U19AI109762-1), the Canadian Institutes of Health Research (IER-143487), the Sanming Project of Medicine in Shenzhen (ZDSYS201504301534057), the Shenzhen Science and Technology Research and Development Project (JCYJ20160427151920801), and the National Natural Science Foundation of China International Cooperation and Exchange Program (816110193). Publisher Copyright: {\textcopyright} 2018. This article contains public sector information licensed under the Open Government Licence v3.0.",
year = "2018",
month = nov,
day = "22",
doi = "10.1093/infdis/jiy245",
language = "English (US)",
volume = "218",
pages = "S471--S474",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
}