Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo)

Robert W. Cross, Chad E. Mire, Krystle N. Agans, Viktoriya Borisevich, Karla A. Fenton, Thomas W. Geisbert

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The domestic ferret was recently described as a uniformly lethal model for 3 species of Ebolavirus. More importantly, this new model utilizes nonadapted wild-type Ebolaviruses. Here, in a proof-of-concept study, we infected ferrets with different variants of the closely related Marburg and Ravn viruses using different doses and routes of exposure. Although ferrets produced a neutralizing humoral response to challenge, we did not observe disease or viremia in any animal. The lack of disease in ferrets underscores the notion that differential mechanisms to immunity among filoviruses exist and may provide a model to better understand how differences contribute to disease.

Original languageEnglish (US)
Pages (from-to)S448-S452
JournalJournal of Infectious Diseases
Volume218
DOIs
StatePublished - Nov 22 2018

Keywords

  • Ebola virus
  • Marburg virus
  • Ravn virus.
  • ferret
  • filovirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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