Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo)

Robert Cross, Chad Mire, Krystle N. Agans, Viktoriya Borisevich, Karla A. Fenton, Thomas Geisbert

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The domestic ferret was recently described as a uniformly lethal model for 3 species of Ebolavirus. More importantly, this new model utilizes nonadapted wild-type Ebolaviruses. Here, in a proof-of-concept study, we infected ferrets with different variants of the closely related Marburg and Ravn viruses using different doses and routes of exposure. Although ferrets produced a neutralizing humoral response to challenge, we did not observe disease or viremia in any animal. The lack of disease in ferrets underscores the notion that differential mechanisms to immunity among filoviruses exist and may provide a model to better understand how differences contribute to disease.

Original languageEnglish (US)
Pages (from-to)S448-S452
JournalThe Journal of infectious diseases
Volume218
Issue number5
DOIs
StatePublished - Nov 22 2018

Fingerprint

Marburgvirus
Ferrets
Ebolavirus
Viremia
Immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo). / Cross, Robert; Mire, Chad; Agans, Krystle N.; Borisevich, Viktoriya; Fenton, Karla A.; Geisbert, Thomas.

In: The Journal of infectious diseases, Vol. 218, No. 5, 22.11.2018, p. S448-S452.

Research output: Contribution to journalArticle

@article{4acacb52601440e3822f9901294f63c1,
title = "Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo)",
abstract = "The domestic ferret was recently described as a uniformly lethal model for 3 species of Ebolavirus. More importantly, this new model utilizes nonadapted wild-type Ebolaviruses. Here, in a proof-of-concept study, we infected ferrets with different variants of the closely related Marburg and Ravn viruses using different doses and routes of exposure. Although ferrets produced a neutralizing humoral response to challenge, we did not observe disease or viremia in any animal. The lack of disease in ferrets underscores the notion that differential mechanisms to immunity among filoviruses exist and may provide a model to better understand how differences contribute to disease.",
author = "Robert Cross and Chad Mire and Agans, {Krystle N.} and Viktoriya Borisevich and Fenton, {Karla A.} and Thomas Geisbert",
year = "2018",
month = "11",
day = "22",
doi = "10.1093/infdis/jiy268",
language = "English (US)",
volume = "218",
pages = "S448--S452",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo)

AU - Cross, Robert

AU - Mire, Chad

AU - Agans, Krystle N.

AU - Borisevich, Viktoriya

AU - Fenton, Karla A.

AU - Geisbert, Thomas

PY - 2018/11/22

Y1 - 2018/11/22

N2 - The domestic ferret was recently described as a uniformly lethal model for 3 species of Ebolavirus. More importantly, this new model utilizes nonadapted wild-type Ebolaviruses. Here, in a proof-of-concept study, we infected ferrets with different variants of the closely related Marburg and Ravn viruses using different doses and routes of exposure. Although ferrets produced a neutralizing humoral response to challenge, we did not observe disease or viremia in any animal. The lack of disease in ferrets underscores the notion that differential mechanisms to immunity among filoviruses exist and may provide a model to better understand how differences contribute to disease.

AB - The domestic ferret was recently described as a uniformly lethal model for 3 species of Ebolavirus. More importantly, this new model utilizes nonadapted wild-type Ebolaviruses. Here, in a proof-of-concept study, we infected ferrets with different variants of the closely related Marburg and Ravn viruses using different doses and routes of exposure. Although ferrets produced a neutralizing humoral response to challenge, we did not observe disease or viremia in any animal. The lack of disease in ferrets underscores the notion that differential mechanisms to immunity among filoviruses exist and may provide a model to better understand how differences contribute to disease.

UR - http://www.scopus.com/inward/record.url?scp=85055698618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055698618&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiy268

DO - 10.1093/infdis/jiy268

M3 - Article

C2 - 29955887

AN - SCOPUS:85055698618

VL - 218

SP - S448-S452

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 5

ER -