Marburg virus infection detected in a common African bat

Jonathan S. Towner, Xavier Pourrut, César G. Albariño, Chimène Nze Nkogue, Brian H. Bird, Gilda Grard, Thomas Ksiazek, Jean Paul Gonzalez, Stuart T. Nichol, Eric M. Leroy

Research output: Contribution to journalArticle

231 Citations (Scopus)

Abstract

Marburg and Ebola viruses can cause large hemorrhagic fever (HF) outbreaks with high case fatality (80-90%) in human and great apes. Identification of the natural reservoir of these viruses is one of the most important topics in this field and a fundamental key to understanding their natural history. Despite the discovery of this virus family almost 40 years ago, the search for the natural reservoir of these lethal pathogens remains an enigma despite numerous ecological studies. Here, we report the discovery of Marburg virus in a common species of fruit bat (Rousettus aegyptiacus) in Gabon as shown by finding virus-specific RNA and IgG antibody in individual bats. These Marburg virus positive bats represent the first naturally infected non-primate animals identified. Furthermore, this is the first report of Marburg virus being present in this area of Africa, thus extending the known range of the virus. These data imply that more areas are at risk for MHF outbreaks than previously realized and correspond well with a recently published report in which three species of fruit bats were demonstrated to be likely reservoirs for Ebola virus.

Original languageEnglish (US)
Article numbere764
JournalPLoS One
Volume2
Issue number8
DOIs
StatePublished - Aug 22 2007
Externally publishedYes

Fingerprint

Marburg virus
Marburgvirus
Virus Diseases
Viruses
Chiroptera
Ebolavirus
viruses
infection
Rousettus
Disease Outbreaks
Fruit
Gabon
fruits
Pongidae
lethal genes
natural history
Fruits
fever
RNA Viruses
Hominidae

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Towner, J. S., Pourrut, X., Albariño, C. G., Nkogue, C. N., Bird, B. H., Grard, G., ... Leroy, E. M. (2007). Marburg virus infection detected in a common African bat. PLoS One, 2(8), [e764]. https://doi.org/10.1371/journal.pone.0000764

Marburg virus infection detected in a common African bat. / Towner, Jonathan S.; Pourrut, Xavier; Albariño, César G.; Nkogue, Chimène Nze; Bird, Brian H.; Grard, Gilda; Ksiazek, Thomas; Gonzalez, Jean Paul; Nichol, Stuart T.; Leroy, Eric M.

In: PLoS One, Vol. 2, No. 8, e764, 22.08.2007.

Research output: Contribution to journalArticle

Towner, JS, Pourrut, X, Albariño, CG, Nkogue, CN, Bird, BH, Grard, G, Ksiazek, T, Gonzalez, JP, Nichol, ST & Leroy, EM 2007, 'Marburg virus infection detected in a common African bat', PLoS One, vol. 2, no. 8, e764. https://doi.org/10.1371/journal.pone.0000764
Towner JS, Pourrut X, Albariño CG, Nkogue CN, Bird BH, Grard G et al. Marburg virus infection detected in a common African bat. PLoS One. 2007 Aug 22;2(8). e764. https://doi.org/10.1371/journal.pone.0000764
Towner, Jonathan S. ; Pourrut, Xavier ; Albariño, César G. ; Nkogue, Chimène Nze ; Bird, Brian H. ; Grard, Gilda ; Ksiazek, Thomas ; Gonzalez, Jean Paul ; Nichol, Stuart T. ; Leroy, Eric M. / Marburg virus infection detected in a common African bat. In: PLoS One. 2007 ; Vol. 2, No. 8.
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