Marine ω-3 fatty acid intake: Associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study

L. Maria Belalcazar; David M. Reboussin; Steven M. Haffner; Rebecca S. Reeves; Dawn C. Schwenke; Ron C. Hoogeveen; F. Xavier Pi-Sunyer; Christie M. Ballantyne

doi:10.2337/dc09-1235

Marine ω-3 fatty acid intake: Associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study

L. Maria Belalcazar, David M. Reboussin, Steven M. Haffner, Rebecca S. Reeves, Dawn C. Schwenke, Ron C. Hoogeveen, F. Xavier Pi-Sunyer, Christie M. Ballantyne

Internal Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

OBJECTIVE - To examine usual marine ω-3 fatty acid (mO-3FA) intake in individuals with diabetes; its association with adiposity, lipid, and glucose control; and its changes with behavioral lifestyle intervention for weight loss. RESEARCH DESIGN AND METHODS - Cross-sectional and 1-year longitudinal analyses were performed on 2,397 Look AHEAD (Action for Health in Diabetes) participants. Look AHEAD is a cardiovascular outcome trial evaluating the effects of intensive lifestyle intervention for weight loss in overweight/obese subjects with type 2 diabetes. RESULTS - Baseline mO-3FA intake was 162±138 mg/day. It was inversely associated with triglycerides (β = -0.41, P < 0.001) and weakly with HDL (β = 4.14, P = 0.050), after multiple covariate adjustment. One-year mO-3FA and fried/sandwich fish intake decreased with intensive lifestyle intervention (P < 0.001). CONCLUSIONS - mO-3FA intake in Look AHEAD participants was low but associated favorably with lipids. These results encourage investigation on the potential benefits of increasing mO-3FA intake in lifestyle interventions for weight loss in individuals with diabetes.

Original language	English (US)
Pages (from-to)	197-199
Number of pages	3
Journal	Diabetes care
Volume	33
Issue number	1
DOIs	https://doi.org/10.2337/dc09-1235
State	Published - Jan 2010

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialized Nursing

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Belalcazar, L. M., Reboussin, D. M., Haffner, S. M., Reeves, R. S., Schwenke, D. C., Hoogeveen, R. C., Pi-Sunyer, F. X., & Ballantyne, C. M. (2010). Marine ω-3 fatty acid intake: Associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study. Diabetes care, 33(1), 197-199. https://doi.org/10.2337/dc09-1235

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title = "Marine ω-3 fatty acid intake: Associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study",

abstract = "OBJECTIVE - To examine usual marine ω-3 fatty acid (mO-3FA) intake in individuals with diabetes; its association with adiposity, lipid, and glucose control; and its changes with behavioral lifestyle intervention for weight loss. RESEARCH DESIGN AND METHODS - Cross-sectional and 1-year longitudinal analyses were performed on 2,397 Look AHEAD (Action for Health in Diabetes) participants. Look AHEAD is a cardiovascular outcome trial evaluating the effects of intensive lifestyle intervention for weight loss in overweight/obese subjects with type 2 diabetes. RESULTS - Baseline mO-3FA intake was 162±138 mg/day. It was inversely associated with triglycerides (β = -0.41, P < 0.001) and weakly with HDL (β = 4.14, P = 0.050), after multiple covariate adjustment. One-year mO-3FA and fried/sandwich fish intake decreased with intensive lifestyle intervention (P < 0.001). CONCLUSIONS - mO-3FA intake in Look AHEAD participants was low but associated favorably with lipids. These results encourage investigation on the potential benefits of increasing mO-3FA intake in lifestyle interventions for weight loss in individuals with diabetes.",

author = "Belalcazar, {L. Maria} and Reboussin, {David M.} and Haffner, {Steven M.} and Reeves, {Rebecca S.} and Schwenke, {Dawn C.} and Hoogeveen, {Ron C.} and Pi-Sunyer, {F. Xavier} and Ballantyne, {Christie M.}",

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AU - Haffner, Steven M.

AU - Reeves, Rebecca S.

AU - Schwenke, Dawn C.

AU - Hoogeveen, Ron C.

AU - Pi-Sunyer, F. Xavier

AU - Ballantyne, Christie M.

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N2 - OBJECTIVE - To examine usual marine ω-3 fatty acid (mO-3FA) intake in individuals with diabetes; its association with adiposity, lipid, and glucose control; and its changes with behavioral lifestyle intervention for weight loss. RESEARCH DESIGN AND METHODS - Cross-sectional and 1-year longitudinal analyses were performed on 2,397 Look AHEAD (Action for Health in Diabetes) participants. Look AHEAD is a cardiovascular outcome trial evaluating the effects of intensive lifestyle intervention for weight loss in overweight/obese subjects with type 2 diabetes. RESULTS - Baseline mO-3FA intake was 162±138 mg/day. It was inversely associated with triglycerides (β = -0.41, P < 0.001) and weakly with HDL (β = 4.14, P = 0.050), after multiple covariate adjustment. One-year mO-3FA and fried/sandwich fish intake decreased with intensive lifestyle intervention (P < 0.001). CONCLUSIONS - mO-3FA intake in Look AHEAD participants was low but associated favorably with lipids. These results encourage investigation on the potential benefits of increasing mO-3FA intake in lifestyle interventions for weight loss in individuals with diabetes.

AB - OBJECTIVE - To examine usual marine ω-3 fatty acid (mO-3FA) intake in individuals with diabetes; its association with adiposity, lipid, and glucose control; and its changes with behavioral lifestyle intervention for weight loss. RESEARCH DESIGN AND METHODS - Cross-sectional and 1-year longitudinal analyses were performed on 2,397 Look AHEAD (Action for Health in Diabetes) participants. Look AHEAD is a cardiovascular outcome trial evaluating the effects of intensive lifestyle intervention for weight loss in overweight/obese subjects with type 2 diabetes. RESULTS - Baseline mO-3FA intake was 162±138 mg/day. It was inversely associated with triglycerides (β = -0.41, P < 0.001) and weakly with HDL (β = 4.14, P = 0.050), after multiple covariate adjustment. One-year mO-3FA and fried/sandwich fish intake decreased with intensive lifestyle intervention (P < 0.001). CONCLUSIONS - mO-3FA intake in Look AHEAD participants was low but associated favorably with lipids. These results encourage investigation on the potential benefits of increasing mO-3FA intake in lifestyle interventions for weight loss in individuals with diabetes.

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Marine ω-3 fatty acid intake: Associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study

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