Marine ω-3 fatty acid intake: Associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study

L. Maria Belalcazar, David M. Reboussin, Steven M. Haffner, Rebecca S. Reeves, Dawn C. Schwenke, Ron C. Hoogeveen, F. Xavier Pi-Sunyer, Christie M. Ballantyne

Research output: Contribution to journalArticle

23 Scopus citations


OBJECTIVE - To examine usual marine ω-3 fatty acid (mO-3FA) intake in individuals with diabetes; its association with adiposity, lipid, and glucose control; and its changes with behavioral lifestyle intervention for weight loss. RESEARCH DESIGN AND METHODS - Cross-sectional and 1-year longitudinal analyses were performed on 2,397 Look AHEAD (Action for Health in Diabetes) participants. Look AHEAD is a cardiovascular outcome trial evaluating the effects of intensive lifestyle intervention for weight loss in overweight/obese subjects with type 2 diabetes. RESULTS - Baseline mO-3FA intake was 162±138 mg/day. It was inversely associated with triglycerides (β = -0.41, P < 0.001) and weakly with HDL (β = 4.14, P = 0.050), after multiple covariate adjustment. One-year mO-3FA and fried/sandwich fish intake decreased with intensive lifestyle intervention (P < 0.001). CONCLUSIONS - mO-3FA intake in Look AHEAD participants was low but associated favorably with lipids. These results encourage investigation on the potential benefits of increasing mO-3FA intake in lifestyle interventions for weight loss in individuals with diabetes.

Original languageEnglish (US)
Pages (from-to)197-199
Number of pages3
JournalDiabetes care
Issue number1
StatePublished - Jan 1 2010


ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this