Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene

Carmelo A. Milano, Lee F. Allen, Paul C. Dolber, Thomas D. Johnson, Howard A. Rockman, Richard A. Bond, Robert J. Lefkowitz

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Transgenic mice with intense cardiac expression of human β-adrenergic receptor gene were engineered and shown to display market improvements in baseline myocardial and left ventricular function. Heart/body weight ratios and histologic appearance were not found to be significantly altered, suggesting that receptor gene expression did not induce pathologic changes. Given the substantial reduction in β-adrenergic receptor density and result reduction in inotropic responsiveness observed in chronic heart failure, these finding represent a novel approach for increasing myocardial function with important clinical implications. (J THORAC CARDIOVASC SURG 1995;109:236-41).

Original languageEnglish (US)
Pages (from-to)236-241
Number of pages6
JournalThe Journal of Thoracic and Cardiovascular Surgery
Volume109
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

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Adrenergic Receptors
Left Ventricular Function
Transgenic Mice
Genes
Heart Failure
Body Weight
Gene Expression

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Milano, C. A., Allen, L. F., Dolber, P. C., Johnson, T. D., Rockman, H. A., Bond, R. A., & Lefkowitz, R. J. (1995). Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene. The Journal of Thoracic and Cardiovascular Surgery, 109(2), 236-241. https://doi.org/10.1016/S0022-5223(95)70384-5

Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene. / Milano, Carmelo A.; Allen, Lee F.; Dolber, Paul C.; Johnson, Thomas D.; Rockman, Howard A.; Bond, Richard A.; Lefkowitz, Robert J.

In: The Journal of Thoracic and Cardiovascular Surgery, Vol. 109, No. 2, 1995, p. 236-241.

Research output: Contribution to journalArticle

Milano, Carmelo A. ; Allen, Lee F. ; Dolber, Paul C. ; Johnson, Thomas D. ; Rockman, Howard A. ; Bond, Richard A. ; Lefkowitz, Robert J. / Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene. In: The Journal of Thoracic and Cardiovascular Surgery. 1995 ; Vol. 109, No. 2. pp. 236-241.
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