Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene

Carmelo A. Milano, Lee F. Allen, Paul C. Dolber, Thomas D. Johnson, Howard A. Rockman, Richard A. Bond, Robert J. Lefkowitz

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Transgenic mice with intense cardiac expression of human β-adrenergic receptor gene were engineered and shown to display market improvements in baseline myocardial and left ventricular function. Heart/body weight ratios and histologic appearance were not found to be significantly altered, suggesting that receptor gene expression did not induce pathologic changes. Given the substantial reduction in β-adrenergic receptor density and result reduction in inotropic responsiveness observed in chronic heart failure, these finding represent a novel approach for increasing myocardial function with important clinical implications. (J THORAC CARDIOVASC SURG 1995;109:236-41).

Original languageEnglish (US)
Pages (from-to)236-241
Number of pages6
JournalThe Journal of thoracic and cardiovascular surgery
Volume109
Issue number2
DOIs
StatePublished - Feb 1995
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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