Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene

Carmelo A. Milano, Lee F. Allen, Paul C. Dolber, Thomas D. Johnson, Howard A. Rockman, Richard A. Bond, Robert J. Lefkowitz

    Research output: Contribution to journalArticle

    17 Scopus citations

    Abstract

    Transgenic mice with intense cardiac expression of human β-adrenergic receptor gene were engineered and shown to display market improvements in baseline myocardial and left ventricular function. Heart/body weight ratios and histologic appearance were not found to be significantly altered, suggesting that receptor gene expression did not induce pathologic changes. Given the substantial reduction in β-adrenergic receptor density and result reduction in inotropic responsiveness observed in chronic heart failure, these finding represent a novel approach for increasing myocardial function with important clinical implications. (J THORAC CARDIOVASC SURG 1995;109:236-41).

    Original languageEnglish (US)
    Pages (from-to)236-241
    Number of pages6
    JournalThe Journal of thoracic and cardiovascular surgery
    Volume109
    Issue number2
    DOIs
    StatePublished - Feb 1995

    ASJC Scopus subject areas

    • Surgery
    • Pulmonary and Respiratory Medicine
    • Cardiology and Cardiovascular Medicine

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