Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene

Carmelo A. Milano, Lee F. Allen, Paul C. Dolber, Thomas D. Johnson, Howard A. Rockman, Richard A. Bond, Robert J. Lefkowitz

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Transgenic mice with intense cardiac expression of human β-adrenergic receptor gene were engineered and shown to display market improvements in baseline myocardial and left ventricular function. Heart/body weight ratios and histologic appearance were not found to be significantly altered, suggesting that receptor gene expression did not induce pathologic changes. Given the substantial reduction in β-adrenergic receptor density and result reduction in inotropic responsiveness observed in chronic heart failure, these finding represent a novel approach for increasing myocardial function with important clinical implications. (J THORAC CARDIOVASC SURG 1995;109:236-41).

Original languageEnglish (US)
Pages (from-to)236-241
Number of pages6
JournalThe Journal of Thoracic and Cardiovascular Surgery
Volume109
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Milano, C. A., Allen, L. F., Dolber, P. C., Johnson, T. D., Rockman, H. A., Bond, R. A., & Lefkowitz, R. J. (1995). Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene. The Journal of Thoracic and Cardiovascular Surgery, 109(2), 236-241. https://doi.org/10.1016/S0022-5223(95)70384-5