Abstract
The protozoan parasite Trypanosoma cruzi causes Chagas disease. Cardiac and adipose tissues are among the early targets of infection and are sites of persistent infection. In the heart and adipose tissue, T. cruzi infection results in an upregulation of pro-inflammatory mediators. In the heart, infection is associated with an increase in the markers of oxidative stress. To date, markers of oxidative stress have not been evaluated in adipose tissue in this infection. Brown and white adipose tissues were obtained from CD-1 mice infected with the Brazil strain of T. cruzi for 15, 30, and 130 days post infection. Protein carbonylation and lipid peroxidation assays were performed on these samples. There was an upregulation of these markers of oxidative stress at all time-points in both white and brown adipose tissue. Determinants of anti-oxidative stress were downregulated at similar time-points. This increase in oxidative stress during T. cruzi infection most likely has a deleterious effect on host metabolism and on the heart.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3159-3165 |
| Number of pages | 7 |
| Journal | Parasitology Research |
| Volume | 113 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2014 |
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ASJC Scopus subject areas
- Parasitology
- veterinary(all)
- Insect Science
- Infectious Diseases
Cite this
Markers of oxidative stress in adipose tissue during Trypanosoma cruzi infection. / Wen, Jian Jun; Nagajyothi, Fnu; Machado, Fabiana S.; Weiss, Louis M.; Scherer, Philipp E.; Tanowitz, Herbert B.; Garg, Nisha.
In: Parasitology Research, Vol. 113, No. 9, 01.09.2014, p. 3159-3165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Markers of oxidative stress in adipose tissue during Trypanosoma cruzi infection
AU - Wen, Jian Jun
AU - Nagajyothi, Fnu
AU - Machado, Fabiana S.
AU - Weiss, Louis M.
AU - Scherer, Philipp E.
AU - Tanowitz, Herbert B.
AU - Garg, Nisha
PY - 2014/9/1
Y1 - 2014/9/1
N2 - The protozoan parasite Trypanosoma cruzi causes Chagas disease. Cardiac and adipose tissues are among the early targets of infection and are sites of persistent infection. In the heart and adipose tissue, T. cruzi infection results in an upregulation of pro-inflammatory mediators. In the heart, infection is associated with an increase in the markers of oxidative stress. To date, markers of oxidative stress have not been evaluated in adipose tissue in this infection. Brown and white adipose tissues were obtained from CD-1 mice infected with the Brazil strain of T. cruzi for 15, 30, and 130 days post infection. Protein carbonylation and lipid peroxidation assays were performed on these samples. There was an upregulation of these markers of oxidative stress at all time-points in both white and brown adipose tissue. Determinants of anti-oxidative stress were downregulated at similar time-points. This increase in oxidative stress during T. cruzi infection most likely has a deleterious effect on host metabolism and on the heart.
AB - The protozoan parasite Trypanosoma cruzi causes Chagas disease. Cardiac and adipose tissues are among the early targets of infection and are sites of persistent infection. In the heart and adipose tissue, T. cruzi infection results in an upregulation of pro-inflammatory mediators. In the heart, infection is associated with an increase in the markers of oxidative stress. To date, markers of oxidative stress have not been evaluated in adipose tissue in this infection. Brown and white adipose tissues were obtained from CD-1 mice infected with the Brazil strain of T. cruzi for 15, 30, and 130 days post infection. Protein carbonylation and lipid peroxidation assays were performed on these samples. There was an upregulation of these markers of oxidative stress at all time-points in both white and brown adipose tissue. Determinants of anti-oxidative stress were downregulated at similar time-points. This increase in oxidative stress during T. cruzi infection most likely has a deleterious effect on host metabolism and on the heart.
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U2 - 10.1007/s00436-014-3977-7
DO - 10.1007/s00436-014-3977-7
M3 - Article
VL - 113
SP - 3159
EP - 3165
JO - Zeitschrift fur Parasitenkunde
JF - Zeitschrift fur Parasitenkunde
SN - 0932-0113
IS - 9
ER -