Mass spectrometric analysis of putative capa-gene products in Musca domestica and Neobellieria bullata

Reinhard Predel, William K. Russell, Shane E. Tichy, David H. Russell, Ronald J. Nachman

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Neuropeptides of the capa-gene are typical of the abdominal neurosecretory system of insects. In this study, we investigated these peptides in two widely distributed and large pest flies, namely Musca domestica and Neobellieria bullata. Using a combination of MALDI-TOF and ESI-QTOF mass spectrometry, periviscerokinins and a pyrokinin were analyzed from single perisympathetic organ preparations. The species-specific peptide sequences differ remarkably between the related dipteran species. These differences could make it possible to develop peptide-analogs with group- or species-specific efficacy.

Original languageEnglish (US)
Pages (from-to)1487-1491
Number of pages5
JournalPeptides
Volume24
Issue number10
DOIs
StatePublished - Oct 2003
Externally publishedYes

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Keywords

  • CAP
  • Insect neuropeptide
  • Mass spectrometry
  • Musca domestica
  • Neobellieria bullata
  • Perisympathetic organs
  • Periviscerokinin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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