Massilia virus, a novel phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean

Rémi N. Charrel, Grégory Moureau, Sarah Temmam, Arezki Izri, Pierre Marty, Philippe Parola, Amelia Travassos Da Rosa, Robert B. Tesh, Xavier De Lamballerie

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

A new virus was isolated from three independent pools of Phlebotomus perniciosus sandflies (Diptera; Psychodidae) trapped in two regions of southeastern France, located 90 miles apart. Microscopic, antigenic and genetic analyses indicate that this novel virus belongs to the genus Phlebovirus in the family Bunyaviridae. The new virus is designated Massilia virus since the first isolate was obtained from sandflies collected in the suburban area of Marseille. The complete genome sequence was determined and used to compare the genetic and phylogenetic relationships of Massilia virus with other phleboviruses. Genetic and antigenic properties were employed to address whether or not Massilia virus should be considered a new species within the genus, or a member of a previously recognized species. Cerebrospinal fluid specimens, collected from local patients with central nervous system infections during the previous four-year period were tested for the presence of Massilia virus RNA, but gave negative results. In conclusion, Massilia virus is proposed as a member of the Sandfly fever Naples virus complex; its public health importance has yet to be determined.

Original languageEnglish (US)
Pages (from-to)519-530
Number of pages12
JournalVector-Borne and Zoonotic Diseases
Volume9
Issue number5
DOIs
StatePublished - Oct 1 2009

Fingerprint

Phlebovirus
Bunyaviridae
Psychodidae
Viruses
Sandfly fever Naples virus
Phlebotomus
Central Nervous System Infections
RNA Viruses
Diptera
France
Cerebrospinal Fluid
Public Health
Genome

Keywords

  • Aedes
  • Arbovirus
  • Chikungunya
  • Culex
  • Dengue
  • Mosquito
  • Rovent-borne
  • Sand fly
  • Vector-borne

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology
  • Virology

Cite this

Charrel, R. N., Moureau, G., Temmam, S., Izri, A., Marty, P., Parola, P., ... De Lamballerie, X. (2009). Massilia virus, a novel phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean. Vector-Borne and Zoonotic Diseases, 9(5), 519-530. https://doi.org/10.1089/vbz.2008.0131

Massilia virus, a novel phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean. / Charrel, Rémi N.; Moureau, Grégory; Temmam, Sarah; Izri, Arezki; Marty, Pierre; Parola, Philippe; Da Rosa, Amelia Travassos; Tesh, Robert B.; De Lamballerie, Xavier.

In: Vector-Borne and Zoonotic Diseases, Vol. 9, No. 5, 01.10.2009, p. 519-530.

Research output: Contribution to journalArticle

Charrel, RN, Moureau, G, Temmam, S, Izri, A, Marty, P, Parola, P, Da Rosa, AT, Tesh, RB & De Lamballerie, X 2009, 'Massilia virus, a novel phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean', Vector-Borne and Zoonotic Diseases, vol. 9, no. 5, pp. 519-530. https://doi.org/10.1089/vbz.2008.0131
Charrel, Rémi N. ; Moureau, Grégory ; Temmam, Sarah ; Izri, Arezki ; Marty, Pierre ; Parola, Philippe ; Da Rosa, Amelia Travassos ; Tesh, Robert B. ; De Lamballerie, Xavier. / Massilia virus, a novel phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean. In: Vector-Borne and Zoonotic Diseases. 2009 ; Vol. 9, No. 5. pp. 519-530.
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