Mast cells and the liver aging process

Fabio Grizzi, Giuseppe Di Caro, Luigi Laghi, Paul Hermonat, Paolo Mazzola, Diane D. Nguyen, Saba Radhi, Jose A. Figueroa, Everardo Cobos, Giorgio Annoni, Maurizio Chiriva-Internati

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

It has now ascertained that the clinical manifestations of liver disease in the elderly population reflect both the cumulative effects of longevity on the liver and the generalized senescence of the organism ability to adjust to metabolic, infectious, and immunologic insults. Although liver tests are not significantly affected by age, the presentation of liver diseases such as viral hepatitis may be subtler in the elderly population than that of younger patients. Human immunosenescence is a situation in which the immune system, particularly T lymphocyte function, deteriorates with age, while innate immunity is negligibly affected and in some cases almost up-regulated.We here briefly review the relationships between the liver aging process and mast cells, the key effectors in a more complex range of innate immune responses than originally though.

Original languageEnglish (US)
Article number9
JournalImmunity and Ageing
Volume10
Issue number1
DOIs
StatePublished - Mar 7 2013

Fingerprint

Cell Aging
Mast Cells
Innate Immunity
Liver Diseases
Liver
Hepatitis
Population
Immune System
T-Lymphocytes

Keywords

  • Ageing
  • Immune system
  • Immunosenescence
  • Inflammation
  • Liver
  • Mast cells

ASJC Scopus subject areas

  • Immunology
  • Aging

Cite this

Grizzi, F., Di Caro, G., Laghi, L., Hermonat, P., Mazzola, P., Nguyen, D. D., ... Chiriva-Internati, M. (2013). Mast cells and the liver aging process. Immunity and Ageing, 10(1), [9]. https://doi.org/10.1186/1742-4933-10-9

Mast cells and the liver aging process. / Grizzi, Fabio; Di Caro, Giuseppe; Laghi, Luigi; Hermonat, Paul; Mazzola, Paolo; Nguyen, Diane D.; Radhi, Saba; Figueroa, Jose A.; Cobos, Everardo; Annoni, Giorgio; Chiriva-Internati, Maurizio.

In: Immunity and Ageing, Vol. 10, No. 1, 9, 07.03.2013.

Research output: Contribution to journalArticle

Grizzi, F, Di Caro, G, Laghi, L, Hermonat, P, Mazzola, P, Nguyen, DD, Radhi, S, Figueroa, JA, Cobos, E, Annoni, G & Chiriva-Internati, M 2013, 'Mast cells and the liver aging process', Immunity and Ageing, vol. 10, no. 1, 9. https://doi.org/10.1186/1742-4933-10-9
Grizzi F, Di Caro G, Laghi L, Hermonat P, Mazzola P, Nguyen DD et al. Mast cells and the liver aging process. Immunity and Ageing. 2013 Mar 7;10(1). 9. https://doi.org/10.1186/1742-4933-10-9
Grizzi, Fabio ; Di Caro, Giuseppe ; Laghi, Luigi ; Hermonat, Paul ; Mazzola, Paolo ; Nguyen, Diane D. ; Radhi, Saba ; Figueroa, Jose A. ; Cobos, Everardo ; Annoni, Giorgio ; Chiriva-Internati, Maurizio. / Mast cells and the liver aging process. In: Immunity and Ageing. 2013 ; Vol. 10, No. 1.
@article{7320d92e873f4fdf9ec00715da266a5a,
title = "Mast cells and the liver aging process",
abstract = "It has now ascertained that the clinical manifestations of liver disease in the elderly population reflect both the cumulative effects of longevity on the liver and the generalized senescence of the organism ability to adjust to metabolic, infectious, and immunologic insults. Although liver tests are not significantly affected by age, the presentation of liver diseases such as viral hepatitis may be subtler in the elderly population than that of younger patients. Human immunosenescence is a situation in which the immune system, particularly T lymphocyte function, deteriorates with age, while innate immunity is negligibly affected and in some cases almost up-regulated.We here briefly review the relationships between the liver aging process and mast cells, the key effectors in a more complex range of innate immune responses than originally though.",
keywords = "Ageing, Immune system, Immunosenescence, Inflammation, Liver, Mast cells",
author = "Fabio Grizzi and {Di Caro}, Giuseppe and Luigi Laghi and Paul Hermonat and Paolo Mazzola and Nguyen, {Diane D.} and Saba Radhi and Figueroa, {Jose A.} and Everardo Cobos and Giorgio Annoni and Maurizio Chiriva-Internati",
year = "2013",
month = "3",
day = "7",
doi = "10.1186/1742-4933-10-9",
language = "English (US)",
volume = "10",
journal = "Immunity and Ageing",
issn = "1742-4933",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Mast cells and the liver aging process

AU - Grizzi, Fabio

AU - Di Caro, Giuseppe

AU - Laghi, Luigi

AU - Hermonat, Paul

AU - Mazzola, Paolo

AU - Nguyen, Diane D.

AU - Radhi, Saba

AU - Figueroa, Jose A.

AU - Cobos, Everardo

AU - Annoni, Giorgio

AU - Chiriva-Internati, Maurizio

PY - 2013/3/7

Y1 - 2013/3/7

N2 - It has now ascertained that the clinical manifestations of liver disease in the elderly population reflect both the cumulative effects of longevity on the liver and the generalized senescence of the organism ability to adjust to metabolic, infectious, and immunologic insults. Although liver tests are not significantly affected by age, the presentation of liver diseases such as viral hepatitis may be subtler in the elderly population than that of younger patients. Human immunosenescence is a situation in which the immune system, particularly T lymphocyte function, deteriorates with age, while innate immunity is negligibly affected and in some cases almost up-regulated.We here briefly review the relationships between the liver aging process and mast cells, the key effectors in a more complex range of innate immune responses than originally though.

AB - It has now ascertained that the clinical manifestations of liver disease in the elderly population reflect both the cumulative effects of longevity on the liver and the generalized senescence of the organism ability to adjust to metabolic, infectious, and immunologic insults. Although liver tests are not significantly affected by age, the presentation of liver diseases such as viral hepatitis may be subtler in the elderly population than that of younger patients. Human immunosenescence is a situation in which the immune system, particularly T lymphocyte function, deteriorates with age, while innate immunity is negligibly affected and in some cases almost up-regulated.We here briefly review the relationships between the liver aging process and mast cells, the key effectors in a more complex range of innate immune responses than originally though.

KW - Ageing

KW - Immune system

KW - Immunosenescence

KW - Inflammation

KW - Liver

KW - Mast cells

UR - http://www.scopus.com/inward/record.url?scp=84874602058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874602058&partnerID=8YFLogxK

U2 - 10.1186/1742-4933-10-9

DO - 10.1186/1742-4933-10-9

M3 - Article

C2 - 23496863

AN - SCOPUS:84874602058

VL - 10

JO - Immunity and Ageing

JF - Immunity and Ageing

SN - 1742-4933

IS - 1

M1 - 9

ER -