Mast cells and the liver aging process

Fabio Grizzi, Giuseppe Di Caro, Luigi Laghi, Paul Hermonat, Paolo Mazzola, Diane D. Nguyen, Saba Radhi, Jose A. Figueroa, Everardo Cobos, Giorgio Annoni, Maurizio Chiriva-Internati

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

It has now ascertained that the clinical manifestations of liver disease in the elderly population reflect both the cumulative effects of longevity on the liver and the generalized senescence of the organism ability to adjust to metabolic, infectious, and immunologic insults. Although liver tests are not significantly affected by age, the presentation of liver diseases such as viral hepatitis may be subtler in the elderly population than that of younger patients. Human immunosenescence is a situation in which the immune system, particularly T lymphocyte function, deteriorates with age, while innate immunity is negligibly affected and in some cases almost up-regulated.We here briefly review the relationships between the liver aging process and mast cells, the key effectors in a more complex range of innate immune responses than originally though.

Original languageEnglish (US)
Article number9
JournalImmunity and Ageing
Volume10
Issue number1
DOIs
StatePublished - Mar 7 2013

Keywords

  • Ageing
  • Immune system
  • Immunosenescence
  • Inflammation
  • Liver
  • Mast cells

ASJC Scopus subject areas

  • Immunology
  • Aging

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    Grizzi, F., Di Caro, G., Laghi, L., Hermonat, P., Mazzola, P., Nguyen, D. D., Radhi, S., Figueroa, J. A., Cobos, E., Annoni, G., & Chiriva-Internati, M. (2013). Mast cells and the liver aging process. Immunity and Ageing, 10(1), [9]. https://doi.org/10.1186/1742-4933-10-9