Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls

Erika Koltai, Zoltan Bori, Peter Osvath, Ferenc Ihasz, Szablics Peter, Geza Toth, Hans Degens, Jörn Rittweger, Istvan Boldogh, Zsolt Radak

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Regular physical exercise has health benefits and can prevent some of the ageing-associated muscle deteriorations. However, the biochemical mechanisms underlying this exercise benefit, especially in human tissues, are not well known. To investigate, we assessed this using miRNA profiling, mRNA and protein levels of anti-oxidant and metabolic proteins in the vastus lateralis muscle of master athletes aged over 65 years and age-matched controls. Master athletes had lower levels of miR-7, while mRNA or protein levels of SIRT3, SIRT1, SOD2, and FOXO1 levels were significantly higher in the vastus lateralis muscle of master athletes compared to muscles of age-matched controls. These results suggest that regular exercise results in better cellular metabolism and antioxidant capacity via maintaining physiological state of mitochondria and efficient ATP production and decreasing ageing-related inflammation as indicated by the lower level of miR-7 in master athletes.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalRedox Biology
Volume19
DOIs
StatePublished - Oct 1 2018

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Athletes
Muscle
Skeletal Muscle
Muscles
Quadriceps Muscle
Exercise
Aging of materials
Messenger RNA
Proteins
Mitochondria
Insurance Benefits
MicroRNAs
Oxidants
Metabolism
Deterioration
Antioxidants
Adenosine Triphosphate
Health
Tissue
Inflammation

Keywords

  • Anti-oxidant
  • Master athlete
  • miRNA
  • Skeletal muscle

ASJC Scopus subject areas

  • Organic Chemistry
  • Clinical Biochemistry

Cite this

Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. / Koltai, Erika; Bori, Zoltan; Osvath, Peter; Ihasz, Ferenc; Peter, Szablics; Toth, Geza; Degens, Hans; Rittweger, Jörn; Boldogh, Istvan; Radak, Zsolt.

In: Redox Biology, Vol. 19, 01.10.2018, p. 46-51.

Research output: Contribution to journalArticle

Koltai, E, Bori, Z, Osvath, P, Ihasz, F, Peter, S, Toth, G, Degens, H, Rittweger, J, Boldogh, I & Radak, Z 2018, 'Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls', Redox Biology, vol. 19, pp. 46-51. https://doi.org/10.1016/j.redox.2018.07.022
Koltai, Erika ; Bori, Zoltan ; Osvath, Peter ; Ihasz, Ferenc ; Peter, Szablics ; Toth, Geza ; Degens, Hans ; Rittweger, Jörn ; Boldogh, Istvan ; Radak, Zsolt. / Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. In: Redox Biology. 2018 ; Vol. 19. pp. 46-51.
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