Mastic oil inhibits the metastatic phenotype of mouse lung adenocarcinoma cells

Heleni Loutrari, Sophia Magkouta, Andreas Papapetropoulos, Charis Roussos

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mastic oil from Pistacia lentiscus variation chia, a natural combination of bioactive terpenes, has been shown to exert anti-tumor growth effects against a broad spectrum of cancers including mouse Lewis lung adenocarcinomas (LLC). However, no studies have addressed its anti-metastatic actions. In this study, we showed that treatment of LLC cells with mastic oil within a range of non-toxic concentrations (0.01-0.04% v/v): (a) abrogated their Matrigel invasion and migration capabilities in transwell assays; (b) reduced the levels of secreted MMP-2; (c) restricted phorbol ester-induced actin remodeling and (d) limited the length of neo-vessel networks in tumor microenvironment in the model of chick embryo chorioallantoic membrane. Moreover, exposure of LLC and endothelial cells to mastic oil impaired their adhesive interactions in a co-culture assay and reduced the expression of key adhesion molecules by endothelial cells upon their stimulation with tumor necrosis factor-alpha. Overall, this study provides novel evidence supporting a multipotent role for mastic oil in prevention of crucial processes related to cancer metastasis.

Original languageEnglish (US)
Pages (from-to)789-801
Number of pages13
JournalCancers
Volume3
Issue number1
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

Fingerprint

Oils
Phenotype
Endothelial Cells
Pistacia
Chorioallantoic Membrane
Neoplasms
Tumor Microenvironment
Terpenes
Phorbol Esters
Chick Embryo
Coculture Techniques
Matrix Metalloproteinases
Adhesives
Actins
Tumor Necrosis Factor-alpha
Neoplasm Metastasis
Adenocarcinoma of lung
Growth

Keywords

  • Adhesion
  • Angiogenesis
  • Invasion
  • Lung cancer
  • Mastic plant essential oil
  • Motility
  • Prevention

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Mastic oil inhibits the metastatic phenotype of mouse lung adenocarcinoma cells. / Loutrari, Heleni; Magkouta, Sophia; Papapetropoulos, Andreas; Roussos, Charis.

In: Cancers, Vol. 3, No. 1, 01.03.2011, p. 789-801.

Research output: Contribution to journalArticle

Loutrari, Heleni ; Magkouta, Sophia ; Papapetropoulos, Andreas ; Roussos, Charis. / Mastic oil inhibits the metastatic phenotype of mouse lung adenocarcinoma cells. In: Cancers. 2011 ; Vol. 3, No. 1. pp. 789-801.
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