Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth

Kelli K. Ryckman, Nils Halvdan Morken, Marquitta J. White, Digna R. Velez, Ramkumar Menon, Stephen J. Fortunato, Per Magnus, Scott M. Williams, Bo Jacobsson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: The purpose of this study was to identify associations between maternal and fetal genetic variants in candidate genes and spontaneous preterm birth (PTB) in a Norwegian population and to determine the effect size of those associations that corroborate a previous study of PTB. Methods: DNA from 434 mother-baby dyads (214 cases and 220 controls) collected from the Norwegian Mother and Child Cohort (MoBa) was examined for association between 1,430 single nucleotide polymorphisms in 143 genes and PTB. These results were compared to a previous study on European Americans (EA) from Centennial Women's Hospital in Nashville, TN, USA. Odds ratios for SNPs that corroborated the Cenntennial study were determined on the combined MoBa and Centennial studies. Results: In maternal samples the strongest results that corroborated the Centennial study were in the prostaglandin E receptor 3 gene (PTGER3; rs977214) (combined genotype p = 3x10-4). The best model for rs977214 was the AG/GG genotypes relative to the AA genotype and resulted in an OR of 0.55 (95% CI = 0.37-0.82, p = 0.003), indicating a protective effect. In fetal samples the most significant association in the combined data was rs854552 in the paraoxonase 1 gene (PON1) (combined allele p = 8x10-4). The best model was the TT genotype relative to the CC/CT genotypes, and resulted in an OR of 1.32 (95% CI = 1.13-1.53, p = 4x10-4). Conclusions: These studies identify single locus associations with preterm birth for both maternal and fetal genotypes in two populations of European ancestry.

Original languageEnglish (US)
Article numbere9040
JournalPLoS One
Volume5
Issue number2
DOIs
StatePublished - Feb 3 2010
Externally publishedYes

Fingerprint

Aryldialkylphosphatase
premature birth
Premature Birth
Genes
Genotype
Mothers
genotype
Receptors, Prostaglandin E, EP3 Subtype
genes
Single Nucleotide Polymorphism
Polymorphism
Nucleotides
infants
odds ratio
single nucleotide polymorphism
Population
prostaglandins
protective effect
aryldialkylphosphatase
DNA

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ryckman, K. K., Morken, N. H., White, M. J., Velez, D. R., Menon, R., Fortunato, S. J., ... Jacobsson, B. (2010). Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. PLoS One, 5(2), [e9040]. https://doi.org/10.1371/journal.pone.0009040

Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. / Ryckman, Kelli K.; Morken, Nils Halvdan; White, Marquitta J.; Velez, Digna R.; Menon, Ramkumar; Fortunato, Stephen J.; Magnus, Per; Williams, Scott M.; Jacobsson, Bo.

In: PLoS One, Vol. 5, No. 2, e9040, 03.02.2010.

Research output: Contribution to journalArticle

Ryckman, KK, Morken, NH, White, MJ, Velez, DR, Menon, R, Fortunato, SJ, Magnus, P, Williams, SM & Jacobsson, B 2010, 'Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth', PLoS One, vol. 5, no. 2, e9040. https://doi.org/10.1371/journal.pone.0009040
Ryckman, Kelli K. ; Morken, Nils Halvdan ; White, Marquitta J. ; Velez, Digna R. ; Menon, Ramkumar ; Fortunato, Stephen J. ; Magnus, Per ; Williams, Scott M. ; Jacobsson, Bo. / Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. In: PLoS One. 2010 ; Vol. 5, No. 2.
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abstract = "Objective: The purpose of this study was to identify associations between maternal and fetal genetic variants in candidate genes and spontaneous preterm birth (PTB) in a Norwegian population and to determine the effect size of those associations that corroborate a previous study of PTB. Methods: DNA from 434 mother-baby dyads (214 cases and 220 controls) collected from the Norwegian Mother and Child Cohort (MoBa) was examined for association between 1,430 single nucleotide polymorphisms in 143 genes and PTB. These results were compared to a previous study on European Americans (EA) from Centennial Women's Hospital in Nashville, TN, USA. Odds ratios for SNPs that corroborated the Cenntennial study were determined on the combined MoBa and Centennial studies. Results: In maternal samples the strongest results that corroborated the Centennial study were in the prostaglandin E receptor 3 gene (PTGER3; rs977214) (combined genotype p = 3x10-4). The best model for rs977214 was the AG/GG genotypes relative to the AA genotype and resulted in an OR of 0.55 (95{\%} CI = 0.37-0.82, p = 0.003), indicating a protective effect. In fetal samples the most significant association in the combined data was rs854552 in the paraoxonase 1 gene (PON1) (combined allele p = 8x10-4). The best model was the TT genotype relative to the CC/CT genotypes, and resulted in an OR of 1.32 (95{\%} CI = 1.13-1.53, p = 4x10-4). Conclusions: These studies identify single locus associations with preterm birth for both maternal and fetal genotypes in two populations of European ancestry.",
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AU - Menon, Ramkumar

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