Maternal folic acid supplementation during pregnancy and early childhood asthma

Sreenivas P. Veeranki, Tebeb Gebretsadik, Edward F. Mitchel, Frances A. Tylavsky, Tina V. Hartert, William O. Cooper, William D. Dupont, Stacy L. Dorris, Terryl J. Hartman, Kecia N. Carroll

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Asthma is one of the most common chronic childhood diseases. While folic acid supplementation around conception helps prevent neural tube defects, an animal model suggests that it may be a risk factor for respiratory diseases, although epidemiologic studies have had conflicting results. We investigated the timing of folic acidcontaining prescription filling during pregnancy and child asthma. Methods: In a retrospective cohort study of 104,428 children, born 1996-2005, and their mothers enrolled in Tennessee Medicaid, we investigated the association of filling folic acid-containing prescriptions during pregnancy and childhood asthma at ages 4.5-6 years. We categorized women into exposure groups based on prescription filling centered around the first trimester: no folic acid prescription exposure, exposure in first trimester only, exposure after first trimester, and exposure in first trimester and beyond. We defined asthma using asthma-specific healthcare visits and medication fills. Using logistic regression models, we investigated the relationship adjusting for potential confounders. Results: Overall 15% of children had asthma. Compared with children born to women with no folic acid prescription exposure, children born to women with exposures in the first trimester only or first trimester and later had increased relative odds of asthma (adjusted odds ratios = 1.2, 95% confidence interval = 1.1, 1.3, and 1.2, 95% confidence interval = 1.2, 1.3); no association was seen in children born to women exposed after the first trimester. Conclusion: Timing of folic acid-containing prescription filling during pregnancy was associated with childhood asthma. Our findings contribute to understanding of the role of prenatal nutritional supplements on child respiratory health.

Original languageEnglish (US)
Pages (from-to)934-941
Number of pages8
JournalEpidemiology
Volume26
Issue number6
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

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Folic Acid
First Pregnancy Trimester
Asthma
Mothers
Prescriptions
Pregnancy
Logistic Models
Odds Ratio
Confidence Intervals
Neural Tube Defects
Medicaid
Epidemiologic Studies
Chronic Disease
Cohort Studies
Animal Models
Retrospective Studies
Delivery of Health Care

ASJC Scopus subject areas

  • Epidemiology

Cite this

Veeranki, S. P., Gebretsadik, T., Mitchel, E. F., Tylavsky, F. A., Hartert, T. V., Cooper, W. O., ... Carroll, K. N. (2015). Maternal folic acid supplementation during pregnancy and early childhood asthma. Epidemiology, 26(6), 934-941. https://doi.org/10.1097/EDE.0000000000000380

Maternal folic acid supplementation during pregnancy and early childhood asthma. / Veeranki, Sreenivas P.; Gebretsadik, Tebeb; Mitchel, Edward F.; Tylavsky, Frances A.; Hartert, Tina V.; Cooper, William O.; Dupont, William D.; Dorris, Stacy L.; Hartman, Terryl J.; Carroll, Kecia N.

In: Epidemiology, Vol. 26, No. 6, 01.10.2015, p. 934-941.

Research output: Contribution to journalArticle

Veeranki, SP, Gebretsadik, T, Mitchel, EF, Tylavsky, FA, Hartert, TV, Cooper, WO, Dupont, WD, Dorris, SL, Hartman, TJ & Carroll, KN 2015, 'Maternal folic acid supplementation during pregnancy and early childhood asthma', Epidemiology, vol. 26, no. 6, pp. 934-941. https://doi.org/10.1097/EDE.0000000000000380
Veeranki SP, Gebretsadik T, Mitchel EF, Tylavsky FA, Hartert TV, Cooper WO et al. Maternal folic acid supplementation during pregnancy and early childhood asthma. Epidemiology. 2015 Oct 1;26(6):934-941. https://doi.org/10.1097/EDE.0000000000000380
Veeranki, Sreenivas P. ; Gebretsadik, Tebeb ; Mitchel, Edward F. ; Tylavsky, Frances A. ; Hartert, Tina V. ; Cooper, William O. ; Dupont, William D. ; Dorris, Stacy L. ; Hartman, Terryl J. ; Carroll, Kecia N. / Maternal folic acid supplementation during pregnancy and early childhood asthma. In: Epidemiology. 2015 ; Vol. 26, No. 6. pp. 934-941.
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AU - Hartert, Tina V.

AU - Cooper, William O.

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