@article{a731679f6ed946d485324b7e8d6018e4,
title = "Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network",
abstract = "Objective: To evaluate the association between maternal fructosamine levels at the time of delivery and stillbirth. Design: Secondary analysis of a case–control study. Setting: Multicentre study of five geographic catchment areas in the USA. Population: All singleton stillbirths with known diabetes status and fructosamine measurement, and representative live birth controls. Main outcome measures: Fructosamine levels in stillbirths and live births among groups were adjusted for potential confounding factors, including diabetes. Optimal thresholds of fructosamine to discriminate stillbirth and live birth. Results: A total of 529 women with a stillbirth and 1499 women with a live birth were included in the analysis. Mean fructosamine levels were significantly higher in women with a stillbirth than in women with a live birth after adjustment (177 ± 3.05 versus 165 ± 2.89 μmol/L, P < 0.001). The difference in fructosamine levels between stillbirths and live births was greater among women with diabetes (194 ± 8.54 versus 162 ± 3.21 μmol/L), compared with women without diabetes (171 ± 2.50 versus 162 ± 2.56 μmol/L). The area under the curve (AUC) for fructosamine level and stillbirth was 0.634 (0.605–0.663) overall, 0.713 (0.624–0.802) with diabetes and 0.625 (0.595–0.656) with no diabetes. Conclusions: Maternal fructosamine levels at the time of delivery were higher in women with stillbirth compared with women with live birth. Differences were substantial in women with diabetes, suggesting a potential benefit of glycaemic control in women with diabetes during pregnancy. The small differences noted in women without diabetes are not likely to justify routine screening in all cases of stillbirth. Tweetable abstract: Maternal serum fructosamine levels are higher in women with stillbirth than in women with live birth, especially in women with diabetes.",
keywords = "Diabetes, fructosamine, gestational diabetes, stillbirth",
author = "E. Arslan and Allshouse, {A. A.} and Page, {J. M.} and Varner, {M. W.} and V. Thorsten and C. Parker and Dudley, {D. J.} and Saade, {G. R.} and Goldenberg, {R. L.} and Stoll, {B. J.} and Hogue, {C. J.} and R. Bukowski and D. Conway and H. Pinar and Reddy, {U. M.} and Silver, {R. M.}",
note = "Funding Information: This investigation was supported by the University of Utah Study Design and Biostatistics Center, with funding in part from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through grant no. 8UL1TR000105 (formerly UL1RR025764). This work, including the design and conduct of the study, the collection, management, analysis and interpretation of the data, and the preparation, review and approval of the article, was supported by grant funding from: the Eunice Kennedy Shriver National Institute of Child Health and Human Development; U10-HD045953, Brown University, Rhode Island; U10-HD045925, Emory University, Georgia; U10-HD045952, University of Texas Medical Branch at Galveston, Texas; U10-HDO45955, University of Texas Health Sciences Center at San Antonio, Texas; U10-HD045944, University of Utah Health Sciences Center, Utah; and U01-HD045954, RTI International, RTP. We acknowledge all of the other study coordinators, physicians, researchers, research nurses and patients that participated in the Stillbirth Collaborative Research Network. Funding Information: This investigation was supported by the University of Utah Study Design and Biostatistics Center, with funding in part from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through grant no. 8UL1TR000105 (formerly UL1RR025764). This work, including the design and conduct of the study, the collection, management, analysis and interpretation of the data, and the preparation, review and approval of the article, was supported by grant funding from: the National Institute of Child Health and Human Development; U10‐HD045953, Brown University, Rhode Island; U10‐HD045925, Emory University, Georgia; U10‐HD045952, University of Texas Medical Branch at Galveston, Texas; U10‐HDO45955, University of Texas Health Sciences Center at San Antonio, Texas; U10‐HD045944, University of Utah Health Sciences Center, Utah; and U01‐HD045954, RTI International, RTP. Eunice Kennedy Shriver Publisher Copyright: {\textcopyright} 2021 John Wiley & Sons Ltd.",
year = "2022",
month = mar,
doi = "10.1111/1471-0528.16922",
language = "English (US)",
volume = "129",
pages = "619--626",
journal = "BJOG: An International Journal of Obstetrics and Gynaecology",
issn = "1470-0328",
publisher = "Wiley-Blackwell",
number = "4",
}