Abstract
Purpose: To investigate if maternal serum pregnancy-associated plasma protein-A levels are affected in hyperemesis gravidarum (HG). Materials and Methods: A prospective case control study was conducted in 169 HG cases who had one or more antepartum hos- pitilization for HG. The control pregnancies were 132 and were selected randomly among all women who had first trimester prenatal screening in antenatal outpatient clinic between 2011 and 2012. Results: Maternal serum pregnancy-associated plasma protein-A levels were significantly higher in hyperemesis gravidarum group compared with control group (p = 0.002 p < 0.05 95% CI). Power analysis of independent sample t-test, two-sided, for pregnancy-associated plasma protein-A was 0.88. Maternal serum free p-human chorionic gonadotropin values were not different between two groups (p > 0.05). Conclusion: Increased pregnancy-associated plasma protein-A levels associated with HG, even after excluding potential cofoundcrs.
Original language | English (US) |
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Pages (from-to) | 534-536 |
Number of pages | 3 |
Journal | Clinical and Experimental Obstetrics and Gynecology |
Volume | 41 |
Issue number | 5 |
DOIs | |
State | Published - 2014 |
Externally published | Yes |
Keywords
- Human chorionic gonadotropin (hCG)
- Hyperemesis gravidarum
- Pregnancy-associated plasma protein-A (PAPP-A)
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology