Maternal vaccination and protective immunity against Zika virus vertical transmission

Chao Shan, Xuping Xie, Huanle Luo, Antonio E. Muruato, Yang Liu, Maki Wakamiya, Jun Ho La, Jin Mo Chung, Scott C. Weaver, Tian Wang, Pei Yong Shi

Research output: Contribution to journalArticle

Abstract

An important goal of the Zika virus (ZIKV) vaccine is to prevent a congenital syndrome in fetuses of pregnant women, but studies directly evaluating maternal vaccination for ZIKV are lacking. Here we report maternal vaccination using a live-attenuated ZIKV vaccine (3ʹUTR-∆10-LAV) in a pregnant mouse model. Maternal immunization with 3ʹUTR-∆10-LAV does not cause any adverse effects on pregnancy, fetal development, or offspring behavior. One maternal immunization fully protects dams against ZIKV infection and in utero transmission. Although neutralizing antibody alone is sufficient to prevent in utero transmission, a higher neutralizing titer is required to protect pregnant mice against in utero transmission than that required to protect non-pregnant mice against viral infection. The immunized dams transfer maternal antibodies to pups, which protect neonates against ZIKV infection. Notably, pregnancy weakens maternal T cell response to 3ʹUTR-∆10-LAV vaccination. Our results suggest that, besides vaccinating non-pregnant individuals, 3ʹUTR-∆10-LAV may also be considered for maternal vaccination.

Original languageEnglish (US)
Article number5677
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

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immunity
viruses
infectious diseases
Viruses
vaccines
Immunization
mice
Immunity
Vaccination
dams
pregnancy
Mothers
antibodies
Dams
Attenuated Vaccines
T-cells
fetuses
Neutralizing Antibodies
Vaccines
Antibodies

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Maternal vaccination and protective immunity against Zika virus vertical transmission. / Shan, Chao; Xie, Xuping; Luo, Huanle; Muruato, Antonio E.; Liu, Yang; Wakamiya, Maki; La, Jun Ho; Chung, Jin Mo; Weaver, Scott C.; Wang, Tian; Shi, Pei Yong.

In: Nature communications, Vol. 10, No. 1, 5677, 01.12.2019.

Research output: Contribution to journalArticle

Shan, C, Xie, X, Luo, H, Muruato, AE, Liu, Y, Wakamiya, M, La, JH, Chung, JM, Weaver, SC, Wang, T & Shi, PY 2019, 'Maternal vaccination and protective immunity against Zika virus vertical transmission', Nature communications, vol. 10, no. 1, 5677. https://doi.org/10.1038/s41467-019-13589-1
Shan, Chao ; Xie, Xuping ; Luo, Huanle ; Muruato, Antonio E. ; Liu, Yang ; Wakamiya, Maki ; La, Jun Ho ; Chung, Jin Mo ; Weaver, Scott C. ; Wang, Tian ; Shi, Pei Yong. / Maternal vaccination and protective immunity against Zika virus vertical transmission. In: Nature communications. 2019 ; Vol. 10, No. 1.
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