Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy

Anne L. Dunlop, Robert N. Taylor, Vin Tangpricha, Stephen Fortunato, Ramkumar Menon

Research output: Contribution to journalArticle

29 Scopus citations


Objective. To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy. Methods. Biospecimens and data were derived from a random sample (N=160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score 7) and assessed the odds of BV for those with 25-OH-D <12ng/mL, folate <5ug/L, and omega-6/omega-3 ratio >15. Results. The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00 ± 8.14ng/mL versus 24.34 ± 11.97ng/mL, P=0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12ng/mL (aOR 5.11, 95 CI: 1.19-21.97) and folate 5ug/L (aOR 7.06, 95 CI: 1.07-54.05). Conclusion. Vitamin D and folate deficiencies were strongly associated with BV (Nugent score 7) during pregnancy.

Original languageEnglish (US)
Article number216217
JournalInfectious Diseases in Obstetrics and Gynecology
StatePublished - 2011


ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Dermatology

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