Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy

Anne L. Dunlop; Robert N. Taylor; Vin Tangpricha; Stephen Fortunato; Ramkumar Menon

doi:10.1155/2011/216217

Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy

Anne L. Dunlop, Robert N. Taylor, Vin Tangpricha, Stephen Fortunato, Ramkumar Menon

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Objective. To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy. Methods. Biospecimens and data were derived from a random sample (N=160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score 7) and assessed the odds of BV for those with 25-OH-D <12ng/mL, folate <5ug/L, and omega-6/omega-3 ratio >15. Results. The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00 ± 8.14ng/mL versus 24.34 ± 11.97ng/mL, P=0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12ng/mL (aOR 5.11, 95 CI: 1.19-21.97) and folate 5ug/L (aOR 7.06, 95 CI: 1.07-54.05). Conclusion. Vitamin D and folate deficiencies were strongly associated with BV (Nugent score 7) during pregnancy.

Original language	English (US)
Article number	216217
Journal	Infectious Diseases in Obstetrics and Gynecology
Volume	2011
DOIs	https://doi.org/10.1155/2011/216217
State	Published - 2011

ASJC Scopus subject areas

Dermatology
Obstetrics and Gynecology
Infectious Diseases

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title = "Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy",

abstract = "Objective. To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy. Methods. Biospecimens and data were derived from a random sample (N=160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score 7) and assessed the odds of BV for those with 25-OH-D <12ng/mL, folate <5ug/L, and omega-6/omega-3 ratio >15. Results. The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00 ± 8.14ng/mL versus 24.34 ± 11.97ng/mL, P=0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12ng/mL (aOR 5.11, 95 CI: 1.19-21.97) and folate 5ug/L (aOR 7.06, 95 CI: 1.07-54.05). Conclusion. Vitamin D and folate deficiencies were strongly associated with BV (Nugent score 7) during pregnancy.",

author = "Dunlop, {Anne L.} and Taylor, {Robert N.} and Vin Tangpricha and Stephen Fortunato and Ramkumar Menon",

year = "2011",

doi = "10.1155/2011/216217",

language = "English (US)",

volume = "2011",

journal = "Infectious Diseases in Obstetrics and Gynecology",

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T1 - Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy

AU - Dunlop, Anne L.

AU - Taylor, Robert N.

AU - Tangpricha, Vin

AU - Fortunato, Stephen

AU - Menon, Ramkumar

PY - 2011

Y1 - 2011

N2 - Objective. To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy. Methods. Biospecimens and data were derived from a random sample (N=160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score 7) and assessed the odds of BV for those with 25-OH-D <12ng/mL, folate <5ug/L, and omega-6/omega-3 ratio >15. Results. The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00 ± 8.14ng/mL versus 24.34 ± 11.97ng/mL, P=0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12ng/mL (aOR 5.11, 95 CI: 1.19-21.97) and folate 5ug/L (aOR 7.06, 95 CI: 1.07-54.05). Conclusion. Vitamin D and folate deficiencies were strongly associated with BV (Nugent score 7) during pregnancy.

AB - Objective. To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy. Methods. Biospecimens and data were derived from a random sample (N=160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score 7) and assessed the odds of BV for those with 25-OH-D <12ng/mL, folate <5ug/L, and omega-6/omega-3 ratio >15. Results. The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00 ± 8.14ng/mL versus 24.34 ± 11.97ng/mL, P=0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12ng/mL (aOR 5.11, 95 CI: 1.19-21.97) and folate 5ug/L (aOR 7.06, 95 CI: 1.07-54.05). Conclusion. Vitamin D and folate deficiencies were strongly associated with BV (Nugent score 7) during pregnancy.

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Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy

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