MCF-specific murine monoclonal antibodies made against AKR-247 MCF virus recognize a unique determinant associated with the gp70-p15(E) complex

M. W. Cloyd, B. Chesebro, J. L. Portis, M. Weir

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Hybridomas obtained from (NFS x AKR)F1 mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of viral antigenic determinant which appeared to be a conformational determinant associated with the env precursor polyprotein (pr80(env)) or its disulfide-linked gp70-p15(E) complex (gp80) but not with free gp70 or p15(E) or any other virion or virus-induced protein.

Original languageEnglish (US)
Pages (from-to)1112-1117
Number of pages6
JournalJournal of Virology
Issue number3
StatePublished - 1982


ASJC Scopus subject areas

  • Immunology

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