MCF-specific murine monoclonal antibodies made against AKR-247 MCF virus recognize a unique determinant associated with the gp70-p15(E) complex

M. W. Cloyd, B. Chesebro, J. L. Portis, M. Weir

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Hybridomas obtained from (NFS x AKR)F1 mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of viral antigenic determinant which appeared to be a conformational determinant associated with the env precursor polyprotein (pr80(env)) or its disulfide-linked gp70-p15(E) complex (gp80) but not with free gp70 or p15(E) or any other virion or virus-induced protein.

Original languageEnglish (US)
Pages (from-to)1112-1117
Number of pages6
JournalJournal of Virology
Volume41
Issue number3
StatePublished - 1982

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Mink Cell Focus-Inducing Viruses
monoclonal antibodies
Monoclonal Antibodies
Inbred AKR Mouse
env Gene Products
viruses
mice
Hybridomas
Disulfides
Virion
Epitopes
hybridomas
Viruses
virion
sulfides
Antigens
epitopes
Antibodies
antigens
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

MCF-specific murine monoclonal antibodies made against AKR-247 MCF virus recognize a unique determinant associated with the gp70-p15(E) complex. / Cloyd, M. W.; Chesebro, B.; Portis, J. L.; Weir, M.

In: Journal of Virology, Vol. 41, No. 3, 1982, p. 1112-1117.

Research output: Contribution to journalArticle

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AU - Cloyd, M. W.

AU - Chesebro, B.

AU - Portis, J. L.

AU - Weir, M.

PY - 1982

Y1 - 1982

N2 - Hybridomas obtained from (NFS x AKR)F1 mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of viral antigenic determinant which appeared to be a conformational determinant associated with the env precursor polyprotein (pr80(env)) or its disulfide-linked gp70-p15(E) complex (gp80) but not with free gp70 or p15(E) or any other virion or virus-induced protein.

AB - Hybridomas obtained from (NFS x AKR)F1 mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of viral antigenic determinant which appeared to be a conformational determinant associated with the env precursor polyprotein (pr80(env)) or its disulfide-linked gp70-p15(E) complex (gp80) but not with free gp70 or p15(E) or any other virion or virus-induced protein.

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