MCF-specific murine monoclonal antibodies made against AKR-247 MCF virus recognize a unique determinant associated with the gp70-p15(E) complex

M. W. Cloyd; B. Chesebro; J. L. Portis; M. Weir

doi:10.1128/jvi.41.3.1112-1117.1982

MCF-specific murine monoclonal antibodies made against AKR-247 MCF virus recognize a unique determinant associated with the gp70-p15(E) complex

M. W. Cloyd, B. Chesebro, J. L. Portis, M. Weir

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Hybridomas obtained from (NFS x AKR)F₁ mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of viral antigenic determinant which appeared to be a conformational determinant associated with the env precursor polyprotein (pr80(env)) or its disulfide-linked gp70-p15(E) complex (gp80) but not with free gp70 or p15(E) or any other virion or virus-induced protein.

Original language	English (US)
Pages (from-to)	1112-1117
Number of pages	6
Journal	Journal of virology
Volume	41
Issue number	3
DOIs	https://doi.org/10.1128/jvi.41.3.1112-1117.1982
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.41.3.1112-1117.1982

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title = "MCF-specific murine monoclonal antibodies made against AKR-247 MCF virus recognize a unique determinant associated with the gp70-p15(E) complex",

abstract = "Hybridomas obtained from (NFS x AKR)F1 mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of viral antigenic determinant which appeared to be a conformational determinant associated with the env precursor polyprotein (pr80(env)) or its disulfide-linked gp70-p15(E) complex (gp80) but not with free gp70 or p15(E) or any other virion or virus-induced protein.",

author = "Cloyd, {M. W.} and B. Chesebro and Portis, {J. L.} and M. Weir",

year = "1982",

doi = "10.1128/jvi.41.3.1112-1117.1982",

language = "English (US)",

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T1 - MCF-specific murine monoclonal antibodies made against AKR-247 MCF virus recognize a unique determinant associated with the gp70-p15(E) complex

AU - Cloyd, M. W.

AU - Chesebro, B.

AU - Portis, J. L.

AU - Weir, M.

PY - 1982

Y1 - 1982

N2 - Hybridomas obtained from (NFS x AKR)F1 mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of viral antigenic determinant which appeared to be a conformational determinant associated with the env precursor polyprotein (pr80(env)) or its disulfide-linked gp70-p15(E) complex (gp80) but not with free gp70 or p15(E) or any other virion or virus-induced protein.

AB - Hybridomas obtained from (NFS x AKR)F1 mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of viral antigenic determinant which appeared to be a conformational determinant associated with the env precursor polyprotein (pr80(env)) or its disulfide-linked gp70-p15(E) complex (gp80) but not with free gp70 or p15(E) or any other virion or virus-induced protein.

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JF - Journal of virology

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MCF-specific murine monoclonal antibodies made against AKR-247 MCF virus recognize a unique determinant associated with the gp70-p15(E) complex

Abstract

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