Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis

Rohit Bakshi, Venkata S R Dandamudi, Mohit Neema, Chitradeep De, Robert A. Bermel

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Evaluation of brain and spinal cord atrophy by magnetic resonance imaging (MRI) has become an increasingly important component of understanding the multiple sclerosis (MS) disease process. These destructive aspects of the disease develop early in the disease course. A growing body of data links brain and spinal cord atrophy to clinical impairment more closely than can be linked with conventional measures of overt lesions. Thus, irreversible tissue damage may be a key factor leading to disease progression. In this review, the authors present the proposed mechanisms leading to central nervous system (CNS) atrophy. They describe the available MRI-based techniques to measure regional and global atrophy of the brain and spinal cord. They compare the rate of atrophy among MS phenotypes and summarize the emerging data linking atrophy to neurological and neuropsychological impairment. Finally, they discuss the effect of disease-modifying immunotherapies on the rate of CNS atrophy in patients with MS. Future research to clarify the etiology and pathophysiology of brain and spinal cord atrophy should provide new targets for therapeutic development.

Original languageEnglish (US)
JournalJournal of Neuroimaging
Volume15
Issue number4 SUPPL.
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Multiple Sclerosis
Atrophy
Spinal Cord
Magnetic Resonance Imaging
Brain
Central Nervous System
Immunotherapy
Disease Progression
Phenotype

Keywords

  • Brain atrophy
  • Cognitive impairment
  • Disability
  • Immunotherapy
  • Multiple sclerosis
  • Spinal cord atrophy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis. / Bakshi, Rohit; Dandamudi, Venkata S R; Neema, Mohit; De, Chitradeep; Bermel, Robert A.

In: Journal of Neuroimaging, Vol. 15, No. 4 SUPPL., 2005.

Research output: Contribution to journalArticle

Bakshi, Rohit ; Dandamudi, Venkata S R ; Neema, Mohit ; De, Chitradeep ; Bermel, Robert A. / Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis. In: Journal of Neuroimaging. 2005 ; Vol. 15, No. 4 SUPPL.
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