@article{79d1811c26a14097a1c2c2c42a930b3e,
title = "Measurement of Histone Methylation Dynamics by One-Carbon Metabolic Isotope Labeling and High-energy Collisional Dissociation Methylation Signature Ion Detection",
abstract = "Accumulating evidence suggests that cellular metabolites and nutrition levels control epigenetic modifications, including histone methylation. However, it is not currently possible to measure the metabolic control of histone methylation. Here we report a novel detection method to monitor methyl transfer from serine to histones through the one-carbon metabolic pathway, using stable-isotope labeling and detection of lysine methylation signature ions generated in high-energy-dissociation (HCD) tandem mass spectrometry. This method is a long-needed tool to study the metabolic control of histone methylation.",
author = "Hui Tang and Bing Tian and Brasier, {Allan R.} and Sowers, {Lawrence C.} and Kangling Zhang",
note = "Funding Information: This research was partially supported by the start-up funds provided by the University of Texas Medical Branch at Galveston School of Medicine to Dr. Zhang and by NIH/NCI grant 1R01CA184097-01 to Sowers and Zhang. We thank Dr. David Konkel, UTMB Institute for Translational Sciences, for critically editing the manuscript. Publisher Copyright: {\textcopyright} The Author(s) 2016.",
year = "2016",
month = aug,
day = "17",
doi = "10.1038/srep31537",
language = "English (US)",
volume = "6",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}