Measurement of Intestinal Edema Using an Impedance Analyzer Circuit

Ravi Radhakrishnan, Kunal Shah, Hasen Xue, Stacey D. Moore-Olufemi, Frederick A. Moore, Norman W. Weisbrodt, Steven J. Allen, Brijesh Gill, Charles S. Cox

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Acute intestinal edema adversely affects intestinal transit, permeability, and contractility. Current resuscitation modalities, while effective, are associated with development of acute intestinal edema. Knowledge of levels of tissue edema would allow clinicians to monitor intestinal tissue water and may help prevent the detrimental effects of edema. However, there is no simple method to measure intestinal tissue water without biopsy. We sought to develop a tissue impedance analyzer to measure tissue edema, without the need for invasive biopsy. Methods: Oscillating voltage input was applied to the analyzer circuit and an oscilloscope measured the voltage output across any load. Rats were randomized to three groups: sham, mild edema (80 mL/kg of NS resuscitation), and severe edema (80 mL/kg of NS resuscitation with intestinal venous hypertension). Intestinal edema was measured by wet-to-dry tissue weight ratio. Bowel impedance was measured and converted to capacitance using a standard curve. Results: Acute intestinal edema causes a significant increase in bowel capacitance. This capacitance can be used to predict tissue water concentration. Conclusion: Using an impedance analyzer circuit, it is possible to measure intestinal edema reliably and quickly. This may prove to be a useful tool in the resuscitation of critically ill patients.

Original languageEnglish (US)
Pages (from-to)106-110
Number of pages5
JournalJournal of Surgical Research
Volume138
Issue number1
DOIs
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Electric Impedance
Edema
Resuscitation
Water
Biopsy
Critical Illness
Permeability
Hypertension
Weights and Measures

Keywords

  • impedance
  • intestinal edema

ASJC Scopus subject areas

  • Surgery

Cite this

Radhakrishnan, R., Shah, K., Xue, H., Moore-Olufemi, S. D., Moore, F. A., Weisbrodt, N. W., ... Cox, C. S. (2007). Measurement of Intestinal Edema Using an Impedance Analyzer Circuit. Journal of Surgical Research, 138(1), 106-110. https://doi.org/10.1016/j.jss.2006.06.009

Measurement of Intestinal Edema Using an Impedance Analyzer Circuit. / Radhakrishnan, Ravi; Shah, Kunal; Xue, Hasen; Moore-Olufemi, Stacey D.; Moore, Frederick A.; Weisbrodt, Norman W.; Allen, Steven J.; Gill, Brijesh; Cox, Charles S.

In: Journal of Surgical Research, Vol. 138, No. 1, 03.2007, p. 106-110.

Research output: Contribution to journalArticle

Radhakrishnan, R, Shah, K, Xue, H, Moore-Olufemi, SD, Moore, FA, Weisbrodt, NW, Allen, SJ, Gill, B & Cox, CS 2007, 'Measurement of Intestinal Edema Using an Impedance Analyzer Circuit', Journal of Surgical Research, vol. 138, no. 1, pp. 106-110. https://doi.org/10.1016/j.jss.2006.06.009
Radhakrishnan, Ravi ; Shah, Kunal ; Xue, Hasen ; Moore-Olufemi, Stacey D. ; Moore, Frederick A. ; Weisbrodt, Norman W. ; Allen, Steven J. ; Gill, Brijesh ; Cox, Charles S. / Measurement of Intestinal Edema Using an Impedance Analyzer Circuit. In: Journal of Surgical Research. 2007 ; Vol. 138, No. 1. pp. 106-110.
@article{bfa7b87d56e64008b42fefd912013fe8,
title = "Measurement of Intestinal Edema Using an Impedance Analyzer Circuit",
abstract = "Background: Acute intestinal edema adversely affects intestinal transit, permeability, and contractility. Current resuscitation modalities, while effective, are associated with development of acute intestinal edema. Knowledge of levels of tissue edema would allow clinicians to monitor intestinal tissue water and may help prevent the detrimental effects of edema. However, there is no simple method to measure intestinal tissue water without biopsy. We sought to develop a tissue impedance analyzer to measure tissue edema, without the need for invasive biopsy. Methods: Oscillating voltage input was applied to the analyzer circuit and an oscilloscope measured the voltage output across any load. Rats were randomized to three groups: sham, mild edema (80 mL/kg of NS resuscitation), and severe edema (80 mL/kg of NS resuscitation with intestinal venous hypertension). Intestinal edema was measured by wet-to-dry tissue weight ratio. Bowel impedance was measured and converted to capacitance using a standard curve. Results: Acute intestinal edema causes a significant increase in bowel capacitance. This capacitance can be used to predict tissue water concentration. Conclusion: Using an impedance analyzer circuit, it is possible to measure intestinal edema reliably and quickly. This may prove to be a useful tool in the resuscitation of critically ill patients.",
keywords = "impedance, intestinal edema",
author = "Ravi Radhakrishnan and Kunal Shah and Hasen Xue and Moore-Olufemi, {Stacey D.} and Moore, {Frederick A.} and Weisbrodt, {Norman W.} and Allen, {Steven J.} and Brijesh Gill and Cox, {Charles S.}",
year = "2007",
month = "3",
doi = "10.1016/j.jss.2006.06.009",
language = "English (US)",
volume = "138",
pages = "106--110",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Measurement of Intestinal Edema Using an Impedance Analyzer Circuit

AU - Radhakrishnan, Ravi

AU - Shah, Kunal

AU - Xue, Hasen

AU - Moore-Olufemi, Stacey D.

AU - Moore, Frederick A.

AU - Weisbrodt, Norman W.

AU - Allen, Steven J.

AU - Gill, Brijesh

AU - Cox, Charles S.

PY - 2007/3

Y1 - 2007/3

N2 - Background: Acute intestinal edema adversely affects intestinal transit, permeability, and contractility. Current resuscitation modalities, while effective, are associated with development of acute intestinal edema. Knowledge of levels of tissue edema would allow clinicians to monitor intestinal tissue water and may help prevent the detrimental effects of edema. However, there is no simple method to measure intestinal tissue water without biopsy. We sought to develop a tissue impedance analyzer to measure tissue edema, without the need for invasive biopsy. Methods: Oscillating voltage input was applied to the analyzer circuit and an oscilloscope measured the voltage output across any load. Rats were randomized to three groups: sham, mild edema (80 mL/kg of NS resuscitation), and severe edema (80 mL/kg of NS resuscitation with intestinal venous hypertension). Intestinal edema was measured by wet-to-dry tissue weight ratio. Bowel impedance was measured and converted to capacitance using a standard curve. Results: Acute intestinal edema causes a significant increase in bowel capacitance. This capacitance can be used to predict tissue water concentration. Conclusion: Using an impedance analyzer circuit, it is possible to measure intestinal edema reliably and quickly. This may prove to be a useful tool in the resuscitation of critically ill patients.

AB - Background: Acute intestinal edema adversely affects intestinal transit, permeability, and contractility. Current resuscitation modalities, while effective, are associated with development of acute intestinal edema. Knowledge of levels of tissue edema would allow clinicians to monitor intestinal tissue water and may help prevent the detrimental effects of edema. However, there is no simple method to measure intestinal tissue water without biopsy. We sought to develop a tissue impedance analyzer to measure tissue edema, without the need for invasive biopsy. Methods: Oscillating voltage input was applied to the analyzer circuit and an oscilloscope measured the voltage output across any load. Rats were randomized to three groups: sham, mild edema (80 mL/kg of NS resuscitation), and severe edema (80 mL/kg of NS resuscitation with intestinal venous hypertension). Intestinal edema was measured by wet-to-dry tissue weight ratio. Bowel impedance was measured and converted to capacitance using a standard curve. Results: Acute intestinal edema causes a significant increase in bowel capacitance. This capacitance can be used to predict tissue water concentration. Conclusion: Using an impedance analyzer circuit, it is possible to measure intestinal edema reliably and quickly. This may prove to be a useful tool in the resuscitation of critically ill patients.

KW - impedance

KW - intestinal edema

UR - http://www.scopus.com/inward/record.url?scp=33846865826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846865826&partnerID=8YFLogxK

U2 - 10.1016/j.jss.2006.06.009

DO - 10.1016/j.jss.2006.06.009

M3 - Article

VL - 138

SP - 106

EP - 110

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 1

ER -