Measurement of refractive index variation of physiological analytes using differential phase OCT

Kirill V. Larin, Taner Akkin, Thomas E. Milner, D. P. Dave, Massoud Motamedi, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.L. Cote, A.V. Priezzhev
Pages31-34
Number of pages4
Volume5325
DOIs
StatePublished - 2004
EventOptical Diagnostics and Sensing IV - San Jose, CA, United States
Duration: Jan 27 2004Jan 27 2004

Other

OtherOptical Diagnostics and Sensing IV
CountryUnited States
CitySan Jose, CA
Period1/27/041/27/04

Fingerprint

Optical tomography
Glucose
Potassium
Refractive index
refractivity
glucose
Calcium chloride
Sodium chloride
tomography
globulins
Urea
magnesium chlorides
Magnesium
calcium chlorides
potassium chlorides
sodium chlorides
Tissue
albumins
ureas
serums

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Larin, K. V., Akkin, T., Milner, T. E., Dave, D. P., Motamedi, M., & Esenaliev, R. (2004). Measurement of refractive index variation of physiological analytes using differential phase OCT. In G. L. Cote, & A. V. Priezzhev (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5325, pp. 31-34) https://doi.org/10.1117/12.532004

Measurement of refractive index variation of physiological analytes using differential phase OCT. / Larin, Kirill V.; Akkin, Taner; Milner, Thomas E.; Dave, D. P.; Motamedi, Massoud; Esenaliev, Rinat.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.L. Cote; A.V. Priezzhev. Vol. 5325 2004. p. 31-34.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Larin, KV, Akkin, T, Milner, TE, Dave, DP, Motamedi, M & Esenaliev, R 2004, Measurement of refractive index variation of physiological analytes using differential phase OCT. in GL Cote & AV Priezzhev (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5325, pp. 31-34, Optical Diagnostics and Sensing IV, San Jose, CA, United States, 1/27/04. https://doi.org/10.1117/12.532004
Larin KV, Akkin T, Milner TE, Dave DP, Motamedi M, Esenaliev R. Measurement of refractive index variation of physiological analytes using differential phase OCT. In Cote GL, Priezzhev AV, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5325. 2004. p. 31-34 https://doi.org/10.1117/12.532004
Larin, Kirill V. ; Akkin, Taner ; Milner, Thomas E. ; Dave, D. P. ; Motamedi, Massoud ; Esenaliev, Rinat. / Measurement of refractive index variation of physiological analytes using differential phase OCT. Proceedings of SPIE - The International Society for Optical Engineering. editor / G.L. Cote ; A.V. Priezzhev. Vol. 5325 2004. pp. 31-34
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