Measurement of refractive index variation of physiological analytes using differential phase OCT

Kirill V. Larin, Taner Akkin, Thomas E. Milner, D. P. Dave, Massoud Motamedi, Rinat O. Esenaliev

Research output: Contribution to journalConference articlepeer-review

Abstract

We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5325
DOIs
StatePublished - Nov 16 2004
EventOptical Diagnostics and Sensing IV - San Jose, CA, United States
Duration: Jan 27 2004Jan 27 2004

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Measurement of refractive index variation of physiological analytes using differential phase OCT'. Together they form a unique fingerprint.

Cite this