Measurement of refractive index variation of physiological analytes using differential phase OCT

Kirill V. Larin; Taner Akkin; Thomas E. Milner; D. P. Dave; Massoud Motamedi; Rinat O. Esenaliev

doi:10.1117/12.532004

Measurement of refractive index variation of physiological analytes using differential phase OCT

Kirill V. Larin, Taner Akkin, Thomas E. Milner, D. P. Dave, Massoud Motamedi, Rinat O. Esenaliev

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Abstract

We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

Original language	English (US)
Pages (from-to)	31-34
Number of pages	4
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5325
DOIs	https://doi.org/10.1117/12.532004
State	Published - 2004
Event	Optical Diagnostics and Sensing IV - San Jose, CA, United States Duration: Jan 27 2004 → Jan 27 2004

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.532004

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title = "Measurement of refractive index variation of physiological analytes using differential phase OCT",

abstract = "We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.",

author = "Larin, \{Kirill V.\} and Taner Akkin and Milner, \{Thomas E.\} and Dave, \{D. P.\} and Massoud Motamedi and Esenaliev, \{Rinat O.\}",

year = "2004",

doi = "10.1117/12.532004",

language = "English (US)",

volume = "5325",

pages = "31--34",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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note = "Optical Diagnostics and Sensing IV ; Conference date: 27-01-2004 Through 27-01-2004",

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TY - JOUR

T1 - Measurement of refractive index variation of physiological analytes using differential phase OCT

AU - Larin, Kirill V.

AU - Akkin, Taner

AU - Milner, Thomas E.

AU - Dave, D. P.

AU - Motamedi, Massoud

AU - Esenaliev, Rinat O.

PY - 2004

Y1 - 2004

N2 - We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

AB - We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

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DO - 10.1117/12.532004

M3 - Conference article

AN - SCOPUS:7644223967

SN - 0277-786X

VL - 5325

SP - 31

EP - 34

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Optical Diagnostics and Sensing IV

Y2 - 27 January 2004 through 27 January 2004

ER -

Measurement of refractive index variation of physiological analytes using differential phase OCT

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