Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy

B. Shim, D. W. Kim, B. H. Kim, T. S. Nam, J. W. Leem, Jin Chung

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

This study examined whether or not the properties of cutaneous nociceptive fibers are altered in the neuropathic state by comparing lumbars 5 and 6 spinal nerve ligation (SNL) rats with sham-operated controls. The rats with the unilateral SNL developed mechanical allodynia in the ipsilateral hind limb, whereas the sham group did not. Two to 5 weeks after the neuropathic or sham surgery, rats were subjected to single fiber-recording experiments to examine the properties of afferent fibers in the sural and plantar nerves. A total of 224 afferents in the C- and Aδ-ranges were characterized in the neuropathic and sham groups. Spontaneous activity was observed in 16 of 155 fibers in the neuropathic group and one of 69 fibers in the sham group. The response threshold of both the C- and Aδ-fibers to mechanical stimuli was lower in the neuropathic group than the sham group. The afferent fibers responsive to heat stimuli were all C-fibers, and none were Aδ-fibers. The response threshold of the C-fibers to the heat stimuli was lower in the neuropathic group than the sham group. The magnitude of the responses of both C- and Aδ-fibers to the suprathreshold intensity of the mechanical stimulus was greater in the neuropathic group than the sham group. However, the magnitude of the responses of C-fibers to the suprathreshold intensity of the heat stimulus in the neuropathic group was not different from that in the sham group. These results suggest that after a partial peripheral nerve injury, the nociceptors on the skin supplied by an uninjured nerve become sensitized to both mechanical and heat stimuli. This nociceptor sensitization can contribute to neuropathic pain.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalNeuroscience
Volume132
Issue number1
DOIs
StatePublished - 2005

Fingerprint

Nociceptors
Peripheral Nervous System Diseases
Myelinated Nerve Fibers
Unmyelinated Nerve Fibers
Hot Temperature
Spinal Nerves
Skin
Ligation
Peripheral Nerve Injuries
Sural Nerve
Hyperalgesia
Neuralgia
Extremities

Keywords

  • Nerve injury
  • Neuropathic pain
  • Nociceptive fibers
  • Single fiber recording
  • Spinal nerve ligation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy. / Shim, B.; Kim, D. W.; Kim, B. H.; Nam, T. S.; Leem, J. W.; Chung, Jin.

In: Neuroscience, Vol. 132, No. 1, 2005, p. 193-201.

Research output: Contribution to journalArticle

Shim, B. ; Kim, D. W. ; Kim, B. H. ; Nam, T. S. ; Leem, J. W. ; Chung, Jin. / Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy. In: Neuroscience. 2005 ; Vol. 132, No. 1. pp. 193-201.
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